{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:31Z","timestamp":1747182571824,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The survival outcomes of lung cancer patients with coexisting chronic kidney disease (CKD) reported in the literature have been conflicting. We evaluate whether the survival of lung cancer patients with and without CKD differ significantly using two different formulas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, multicenter, propensity\u2010matched study of lung cancer patients with and without CKD was conducted. CKD was defined as an estimated glomerular filtration rate (eGFR) &lt; 60 mL\/minute. Kaplan\u2013Meier survival analysis was used to determine survival differences between CKD and non\u2010CKD patients using the Cockcroft\u2013Gault formula (CKD\u2013CG) compared to the Chronic Kidney Disease Epidemiology Collaboration Formula (CKD\u2010EPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline clinical characteristics did not differ statistically significantly between the groups. The CKD\u2010CG formula demonstrated median survival of 10.61 months (95% confidence interval [CI] 9.33\u201311.89) for the non\u2010CKD group compared to 10.58 months (95% CI 9.03\u201312.13) for the CKD group (<jats:italic>P<\/jats:italic> = 0.76). The CKD\u2010EPI formula demonstrated median survival of 9.10 months (95% CI 8.01\u201310.20) for the non\u2010CKD group compared to 7.59 months (95% CI 6.50\u20138.68) for the CKD group (<jats:italic>P<\/jats:italic> = 0.19). Cox regression analysis using both models revealed that CKD is not an independent risk factor for mortality in lung cancer patients. Although the CKD\u2010EPI formula revealed an increased risk of mortality and the CKD\u2010CG formula revealed decreased survival, these results were not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lung cancer survival did not differ significantly between CKD and non\u2010CKD patients using either formula.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12946","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T15:08:15Z","timestamp":1545836895000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lung cancer outcome in the setting of chronic kidney disease: Does the glomerular filtration estimation formula matter?"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-0288","authenticated-orcid":false,"given":"Ming\u2010Shian","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery Chang Gung Memorial Hospital at ChiaYi  Putz City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010I","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery Chang Gung Memorial Hospital at Keelung  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chang Gung Memorial Hospital at ChiaYi  Putz City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Chao","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery Chang Gung Memorial Hospital at ChiaYi  Putz City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Hsi","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery Chang Gung Memorial Hospital at ChiaYi  Putz City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Huang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital at ChiaYi and Department of Respiratory Therapy, Chang Gung University  Putz City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization International Agency for Research on Cancer GLOBOCAN 2012: Estimated cancer incidence mortality and prevalence worldwide in 2012.Lung Cancer. 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