{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:31Z","timestamp":1747182571885,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2014R1A5A2009242","2016R1A1A1A05005315"],"award-info":[{"award-number":["2014R1A5A2009242","2016R1A1A1A05005315"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non\u2010small cell lung cancer (NSCLC) after surgical resection. Twenty\u2010three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease\u2010free survival (DFS) were analyzed. Among the 23 SNPs investigated, <jats:italic>TSC2<\/jats:italic> rs30259G &gt; A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21\u20132.91, <jats:italic>P<\/jats:italic> = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15\u20132.38, <jats:italic>P<\/jats:italic> = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever\u2010smokers, and stage I, but not in adenocarcinoma, never\u2010smokers, and stage II\u2013IIIA. The results suggest that <jats:italic>TSC2<\/jats:italic> rs30259G &gt; A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.<\/jats:p>","DOI":"10.1111\/1759-7714.12951","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T11:08:26Z","timestamp":1545822506000},"page":"335-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>TSC2<\/i> genetic variant and prognosis in non\u2010small cell lung cancer after curative surgery"],"prefix":"10.1111","volume":"10","author":[{"given":"Yong Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook Kyung","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell 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Program Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung Bae","family":"Lee","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, Kyungpook National University Chilgok Hospital  Daegu South Korea"},{"name":"Department of Thoracic Surgery, School of Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Min","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Kee","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Research Collaboration Center in Kyungpook National University Hospital and School of Medicine, Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangki","family":"Seok","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, Kyungpook National University Chilgok Hospital  Daegu South Korea"},{"name":"Department of Thoracic Surgery, School of Medicine Kyungpook National University  Daegu Republic of Korea"},{"name":"Department of Thoracic Surgery Soonchunhyang University Gumi Hospital  Gumi South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukki","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Seoul National University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Soo","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu South Korea"},{"name":"Lung Cancer Center, Kyungpook National University Chilgok Hospital  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ick","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu South 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