{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:36:28Z","timestamp":1791995788410,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant pleural mesothelioma (MPM) is an aggressive tumor, associated with poor prognosis. There is a lack of information about the clinical and pathological features related with survival in the Latin American population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The MeSO\u2010CLICaP registry identified 302 patients with advanced MPM diagnosed and treated between January 2008 and March 2016. The Cox model was applied to determine the variables associated with survival. A random forest tree model was built to predict the response to first\u2010line chemotherapy among Latin American patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 61.1 years (SD 10.6 years), 191 (63.2%) were men, 65.9% were ever smokers, and 38.7% had previous exposure to asbestos. A total of 237 (78.5%) had epithelioid tumors, and 188 (62.3%) and 114 (37.7%) cases had stage\u2009III or IV MPM, respectively. A total of 49 patients (16.2%) underwent pleurectomy, 57 (18.9%) received radiotherapy, and 279 patients received first\u2010line platinum\u2010based chemotherapy. The overall response rate to first\u2010line chemotherapy was 40.4%, progression\u2010free survival to first\u2010line treatment was 5.7 months (95% CI 4.9\u20136.5), and 63 (20.8%) patients had pemetrexed maintenance. The median overall survival was 16.8 months (95% CI 13.0\u201320.5), and multivariate analysis found that stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.013), and pleurodesis (<jats:italic>P<\/jats:italic>\u2009=\u20090.048), were independent prognostic factors for first\u2010line overall survival. The model to predict response to first\u2010line chemotherapy obtained a 0.98 area under the curve, a sensitivity of 93%, and a specificity of 95% for detecting responders and non\u2010responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identifies factors associated with clinical benefit from chemotherapy among advanced MPM Latin American patients, emphasizing the impact of histology and the clinical benefit of chemotherapy on outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12967","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T05:59:47Z","timestamp":1549000787000},"page":"508-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics and long\u2010term outcomes of advanced pleural mesothelioma in Latin America (MeSO\u2010CLICaP)"],"prefix":"10.1111","volume":"10","author":[{"given":"Leonardo","family":"Rojas","sequence":"first","affiliation":[{"name":"Clinical Oncology Department, Organizaci\u00f3n Sanitas Internacional University Clinic Colombia  Bogota Colombia"},{"name":"Clinical and Traslational Oncology Group Country Clinic  Bogota Colombia"},{"name":"Foundation for Clinical and Applied Cancer Research \u2013 FICMAC  Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s F.","family":"Cardona","sequence":"additional","affiliation":[{"name":"Clinical and Traslational Oncology Group Country Clinic  Bogota Colombia"},{"name":"Foundation for Clinical and Applied Cancer Research \u2013 FICMAC  Bogota Colombia"},{"name":"Clinical Research and Biology Systems Department El Bosque University  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Trejo\u2010Rosales","sequence":"additional","affiliation":[{"name":"National Medical Center, Century XXI, IMSS  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zyanya Lucia","family":"Zatarain\u2010Barr\u00f3n","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit National Cancer Institute  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura\u2010Alejandra","family":"Ram\u00edrez\u2010Tirado","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit National Cancer Institute  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ruiz\u2010Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Foundation for Clinical and Applied Cancer Research \u2013 FICMAC  Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00fal","family":"Campos G\u00f3mez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department State Oncology Center ISSEMyM  Toluca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Corrales","sequence":"additional","affiliation":[{"name":"Oncology Department San Juan de Dios Hospital  San Jos\u00e9 Costa Rica Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Oblitas","sequence":"additional","affiliation":[{"name":"Oncology Unit Venezuela  Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwing","family":"Bacon","sequence":"additional","affiliation":[{"name":"Oncology Department Roberto Calder\u00f3n Hospital  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Section Alexander Fleming Institute  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladmir C. 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