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Use of 18F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography during initial diagnosis of these early\u2010stage lesions has been increasing. Traditionally, positron emission tomography\/computed tomography scans have been utilized for mediastinal nodal staging and to rule out distant metastases in suspected early\u2010stage NSCLC. In clinically node\u2010negative NSCLC, the use of sublobar resection and selective lymph node dissection has been increasing as a therapeutic option. The higher rate of locoregional recurrences after limited resection and the significant incidence of occult lymph node metastases underscores the need to further stratify clinically node\u2010negative NSCLC in order to select patients for limited resection versus lobectomy with complete mediastinal lymph node dissection. In this report, we review the published data, and discuss the significance and potential role of 18F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography evaluation for clinically node\u2010negative NSCLC. Consequently, the literature review demonstrates that maximum standardized uptake value is a predictive factor for occult nodal metastasis with an accuracy of 55\u201377%. In addition, maximum standardized uptake value is a predictor for worse overall, as well as disease\u2010free, survival.<\/jats:p>","DOI":"10.1111\/1759-7714.12978","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T20:48:15Z","timestamp":1548190095000},"page":"413-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["18F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography in the evaluation of clinically node\u2010negative non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-4896","authenticated-orcid":false,"given":"Yusuke","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery Sagamihara Kyodo Hospital  Sagamihara Japan"},{"name":"Department of General Thoracic Surgery Teikyo University School of Medicine  Tokyo 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