{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:36:47Z","timestamp":1769762207138,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601411"],"award-info":[{"award-number":["81601411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the gene expression profile of a set of candidate genes for a better understanding of the molecular mechanism underlying the pathogenesis of thymoma with or without myasthenia gravis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thymoma patients and thymoma patients with myasthenia gravis were analyzed using microarray profiling to identify significant changes in gene expression of autoimmune regulator pathway genes including <jats:italic>AIRE<\/jats:italic>, <jats:italic>IL\u20107R<\/jats:italic>, <jats:italic>CHRNA3<\/jats:italic>, <jats:italic>SYMD1<\/jats:italic>, <jats:italic>THRA<\/jats:italic>, and <jats:italic>CAV3.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across all of our samples, we found that 1484 mRNAs were upregulated and 770 were downregulated in thymoma patients compared with thymoma with myasthenia gravis patients. Gene ontology and pathway analysis revealed that a large number of genes participated in cellular functions for humoral immune response, sequence\u2010specific DNA binding RNA polymerase\u2009II transcription factor activity, positive regulation of gene expression, regulation of neuron projection development, extracellular ligand\u2010gated ion channel activity, positive regulation of striated muscle cell differentiation, and regulation of nuclear factor\u2010kappaB import into the nucleus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results revealed genetic differences between thymomas and myasthenia gravis, and identified the key candidate genes\/pathways for molecular mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.12980","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T05:36:11Z","timestamp":1549604171000},"page":"564-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alteration in gene expression profile of thymomas with or without myasthenia gravis linked with the nuclear factor\u2010kappaB\/autoimmune regulator pathway to myasthenia gravis pathogenesis"],"prefix":"10.1111","volume":"10","author":[{"given":"Feng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jie","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Yu","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-1961","authenticated-orcid":false,"given":"Fan\u2010Jie","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis 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