{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:16:31Z","timestamp":1783703791477,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This prospective study investigated the association between tooth loss and upper gastrointestinal (UGI) cancer mortality in the Linxian Dysplasia Nutrition Intervention Trial Cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects were categorized into three groups according to age at baseline. No missing teeth and less or greater than median tooth loss in each group was defined as none, moderate, and severe, respectively. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Through 30 September 2015, 541 esophageal squamous cell carcinoma (ESCC), 284 gastric cardia carcinoma (GCC), and 77 gastric non\u2010cardia carcinoma (GNCC) deaths occurred. In the six\u2010year follow\u2010up, severe tooth loss was associated with an increased risk of GCC mortality (HR 1.55, 95% CI 1.06\u20132.18). In the 15\u2010year follow\u2010up, moderate tooth loss increased the ESCC mortality risk by 58% (HR 1.58, 95% CI 1.06\u20132.35), while severe loss increased the GCC mortality risk by 30% (HR 1.30, 95% CI 1.03\u20131.64). In the 30\u2010year follow\u2010up, moderate tooth loss increased the risk of ESCC mortality (HR 1.34, 95% CI 1.01\u20131.76). In subjects aged &lt; 55 at baseline and men, moderate tooth loss had 53% and 52% higher risks of ESCC mortality (HR\n                      <jats:sub>&lt;55 years<\/jats:sub>\n                      1.53, 95% CI 1.06\u20132.05; HRmen 1.52, 95% CI 1.01\u20132.28). No significant association was observed for GNCC in any subjects or subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate tooth loss increased the risk of ESCC mortality, particularly in younger subjects and men. Severe tooth loss increased the risk of GCC mortality. Future studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.13037","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T14:48:57Z","timestamp":1552920537000},"page":"966-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association between tooth loss and upper gastrointestinal cancer: A 30\u2010year follow\u2010up of the Linxian Dysplasia Nutrition Intervention Trial Cohort"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-6733","authenticated-orcid":false,"given":"Su","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing, 10021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing, 10021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Zhejiang University School of Medicine  Hangzhou, 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing, 10021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-0871","authenticated-orcid":false,"given":"You\u2010Lin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing, 10021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.11.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2003.tb00761.x"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"29","article-title":"Tooth loss in the very old: 13\u201315\u2010year incidence among elderly Iowans","volume":"30","author":"Joseph WJ","year":"2010","journal-title":"Community Dent Oral Epidemiol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.107424"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.081695"},{"issue":"11","key":"e_1_2_7_7_1","first-page":"21893","article-title":"Tooth loss and risk of oral squamous cell carcinoma in Chinese Han population","volume":"8","author":"Zuo C","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15203"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149653"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0491"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29710"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.062331"},{"issue":"3","key":"e_1_2_7_13_1","first-page":"175","article-title":"Possible explanations for the tooth loss and cardiovascular disease relationship","volume":"3","author":"Joshipura KJ","year":"2017","journal-title":"Ann Periodontol"},{"issue":"1444","key":"e_1_2_7_14_1","first-page":"68","article-title":"A morbidity\/mortality analysis of a tertiary level upper gastrointestinal\/hepatopancreaticobiliary surgical unit","volume":"129","author":"Wickremesekera SK","year":"2016","journal-title":"N Z Med J"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_16_1","unstructured":"Globocan 2018: Estimated Cancer Incidence Mortality and Prevalence Worldwide in 2018. 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