{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:44:14Z","timestamp":1792107854246,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Capital Clinical Characteristics Foundation","award":["Z151100004015200"],"award-info":[{"award-number":["Z151100004015200"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have documented a high incidence of toxicity in patients with ultra\u2010central non\u2010small cell lung cancer (UC\u2010NSCLC) treated with stereotactic body radiation therapy (SBRT). However, these studies mainly focused on early stage patients and included small sample populations. We reviewed the outcomes and toxicity of SBRT in patients with advanced stage UC\u2010NSCLC treated at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one consecutive patients with advanced UC\u2010NSCLC treated with SBRT using a regular regimen of 35\u2009Gy administered in five fractions between December 2014 and August 2017 were reviewed. UC was defined as tumors abutting or overlapping the trachea or the proximal bronchial tree. We included locally advanced patients who were unfit or unwilling to receive conventional chemoradiotherapy and patients with metastatic or postoperative recurrent disease. Clinical outcomes, dosimetric parameters, and SBRT toxicity were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 63\u2009years (range: 35\u201382), and the median tumor diameter was 6.8 cm (range: 2.1\u201312.4). The overall median follow\u2010up duration was 17\u2009months (25.5 months for surviving patients). The median local control was 17\u2009months for stage III patients and 11\u2009months for stage IV or recurrent patients. Grade 3 or higher toxicity was observed in 9.8% of patients: G3 radiation pneumonitis (5.9%) and possible treatment\u2010related death (3.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SBRT with a moderate dose in 4\u20136 fractions is effective and tolerable for patients with advanced stage UC\u2010NSCLC. However, caution should be taken considering possible treatment\u2010related death. Further studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13105","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T04:25:45Z","timestamp":1560313545000},"page":"1567-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Outcomes and toxicity of stereotactic body radiation therapy for advanced stage ultra\u2010central non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"10","author":[{"given":"Yang","family":"Cong","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangying","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing 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