{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:52Z","timestamp":1747182592288,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B04032467"],"award-info":[{"award-number":["2017R1D1A1B04032467"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the prognostic impact of epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>) mutation and anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>) rearrangement for the overall survival (OS) of patients with surgically treated lung adenocarcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 689 patients with stage I\u2013III lung adenocarcinomas (male:female = 334:355; median age, 64\u2009years) underwent complete surgical resection between 2007 and 2013. The prognostic impact of <jats:italic>EGFR<\/jats:italic> mutation and <jats:italic>ALK<\/jats:italic> rearrangement on OS was analyzed using Cox regression analysis. Certain clinicopathological prognostic factors (i.e., age, sex, smoking status, nodule type, solid portion size, pathologic stage, adenocarcinoma subtype, and history of adjuvant chemotherapy) were included for adjustments of the hazard ratio (HR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\n<jats:italic>EGFR<\/jats:italic> mutation was observed in 438 patients (64%) and <jats:italic>ALK<\/jats:italic> rearrangement was seen in 28 patients (4%). Multivariable\u2010adjusted Cox regression demonstrated that the prognostic effect of <jats:italic>EGFR<\/jats:italic> mutation on OS differed by age (HR, exp.[\u22125.199\u2009+\u20090.064<jats:sup>*<\/jats:sup>age]). The adjusted HR for <jats:italic>EGFR<\/jats:italic> mutation was 0.14 (95% CI: 0.05\u20130.36; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at 50\u2009years, 0.26 (95% CI: 0.15\u20130.46; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at 60\u2009years, and 0.50 (95% CI: 0.31\u20130.81; <jats:italic>P<\/jats:italic> = 0.005) at 70\u2009years. However, the effect of <jats:italic>ALK<\/jats:italic> rearrangement on OS was without statistical significance (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\n<jats:italic>EGFR<\/jats:italic> mutation was independently prognostic of the long\u2010term outcomes of patients with surgically treated lung adenocarcinomas. A more favorable prognostic effect was seen in younger than in older patients. <jats:italic>ALK<\/jats:italic> rearrangement was not associated with OS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13128","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:48:23Z","timestamp":1560937703000},"page":"1619-1627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The prognostic implications of <i>EGFR<\/i> mutation and <i>ALK<\/i> rearrangement for the long\u2010term outcomes of patients with resected lung adenocarcinomas"],"prefix":"10.1111","volume":"10","author":[{"given":"Hyungjin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiology Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Radiation Medicine Seoul National University Medical Research Center  Seoul 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