{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:42:26Z","timestamp":1793392946929,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0902003"],"award-info":[{"award-number":["2016YFC0902003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010eluting beads bronchial arterial chemoembolization (DEB\u2010BACE) can embolize the tumor\u2010feeding artery and also be loaded with antitumor drugs, which can be released slowly into the local tumor environment. The effect of DEB\u2010BACE in patients with lung cancer remains unclear. We evaluated the efficacy and safety of DEB\u2010BACE with gemcitabine\u2010loaded CalliSpheres beads in patients with non\u2010small cell lung cancer (NSCLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From May 2017 to December 2018, six patients with NSCLC who were ineligible or refused to receive standard treatment underwent DEB\u2010BACE with gemcitabine\u2010loaded CalliSpheres beads. The primary endpoint was the objective response rate (ORR). The secondary endpoints were progression\u2010free survival (PFS), overall survival (OS), and quality of life. Safety was evaluated by the occurrences of adverse events and serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were treated with DEB\u2010BACE loaded with gemcitabine (800\u2009mg) using CalliSpheres beads. Five patients also received transarterial infusion with nedaplatin (80\u2013100\u2009mg). Of the six patients, five underwent a second session of DEB\u2010BACE, with intervals of one\u2009month between the first and second session. The median follow\u2010up time was 16.5 months (7.0\u201323.0 months). ORR and disease control rate were 50.0% and 100.0%, 50.0% and 83.3%, 50.0% and 66.7% respectively at 2, 4, and 6 months after DEB\u2010BACE. One patient maintained a partial response and the other five had progressive disease, of whom two patients died and the other three remained alive receiving targeted therapy, radiotherapy, transarterial infusion or thermal ablation. The median PFS was 8.0 months (4\u201323\u2009months), and the 6\u2010 and 12 month PFS rates were 66.7% and 16.7%, respectively. The median OS was 16.5 months (7\u201323\u2009months), and the six and 12 month OS rates were 100.0% and 66.7%, respectively. Hemoptysis, cough and dyspnea disappeared after DEB\u2010BACE in four patients. Global quality of life, physical and emotional functioning were all significantly improved at two months (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were no serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DEB\u2010BACE with gemcitabine\u2010loaded CalliSpheres beads is a feasible and well\u2010tolerated treatment for patients with NSCLC who are ineligible or refuse to receive standard treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13139","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T05:25:12Z","timestamp":1563513912000},"page":"1770-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["The efficacy of drug\u2010eluting beads bronchial arterial chemoembolization loaded with gemcitabine for treatment of non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-2409","authenticated-orcid":false,"given":"Zhixin","family":"Bie","sequence":"first","affiliation":[{"name":"Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanming","family":"Li","sequence":"additional","affiliation":[{"name":"Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-650X","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Li","sequence":"additional","affiliation":[{"name":"Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu199"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000141"},{"key":"e_1_2_6_6_1","first-page":"1329","article-title":"Oral bioavailability and first\u2010pass effects","volume":"25","author":"Kwan KC","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-013-0576-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2017.06.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-015-1208-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0136"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1368-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033819830751"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4566-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2017.9.18532"},{"key":"e_1_2_6_16_1","unstructured":"NCI. National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Available from URL:http:\/\/ctep.cancer.gov\/protocol\u00a0Development\/electronic_applications\/ctc.htm."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115898"},{"key":"e_1_2_6_18_1","first-page":"917","article-title":"A case of a 91\u2010year\u2010old patient with advanced squamous cell lung cancer complicated with renal dysfunction successfully treated with trans\u2010arterial chemo\u2010embolization","volume":"40","author":"Kunisada K","year":"2013","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172571"},{"key":"e_1_2_6_20_1","first-page":"1407","article-title":"Transcatheter arterial chemoembolization with super absorbent polymer microspheres for a large lung cystic adenocarcinoma in the left pulmonary cavity","volume":"42","author":"Kennoki N","year":"2015","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_21_1","first-page":"1827","article-title":"Trans\u2010arterial chemoembolization therapy for refractory advanced non\u2010small cell lung cancer with spherical embolic material\u2010\u2010a single case report","volume":"42","author":"Kennoki N","year":"2015","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_93_17"},{"key":"e_1_2_6_23_1","first-page":"539","article-title":"Efficacy for artery chemoembolization combined with radiofrequency ablation in the treatment of advanced non\u2010small cell lung cancer","volume":"96","author":"Yang XG","year":"2016","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0848-1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(16)60133-9"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.13139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:31:31Z","timestamp":1694302291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/1759-7714.13139"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13139","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"2019-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}