{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:55:56Z","timestamp":1761562556940,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0904900"],"award-info":[{"award-number":["2016YFC0904900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Taxane\u2010based chemotherapy is widely used in lung cancer. ABCB1 have a role in the prediction of treatment response and toxicity of chemotherapy in solid tumors. In this retrospective study, we investigated ABCB1 polymorphism on response and toxicity in taxane\u2010based chemotherapy in lung cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 122 lung cancer patients who received taxane\u2010based chemotherapy were included in this study. Fluorescence in situ hybridization (FISH) was used for ABCB1 polymorphism detection. Turbidimetric inhibition immunoassay was used for pharmacokinetic analysis. Statistical analysis was performed using SPSS 20.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of the ABCB1 2677 site TT\/TG\/GG genotype was 32.8%, 43.4% and 23.8%, respectively and the frequency of the 3435 sites the TT\/TC\/CC genotype was 13.9%, 44.3% and 41.8%, respectively. The occurrence of neurotoxicity was higher in patients who had ABCB1 3435 site mutation (TT 88.2%, TC 22.2%, CC 21.6% <jats:italic>P<\/jats:italic> =\u20090.004). There was no significant difference between ABCB1 genotypes with regard to other chemotherapy\u2010induced toxicity. For non\u2010small cell lung cancer (NSCLC) patients, those harboring ABCB1 2677 and 3435 site wild\u2010type patients had longer median progression\u2010free survival (PFS) in the paclitaxel subgroup (3435 site: TT 3.87 vs. TC 9.50 vs. CC 14.13\u2009months; <jats:italic>P<\/jats:italic> &lt;\u20090.001; 2677 site: TT 4.37 vs. TG 9.73 vs. GG 12.1 months; <jats:italic>P<\/jats:italic> =\u20090.013). The area under the concentration\u2010time curve (AUC) of 20 patients treated with docetaxel increased for ABCB1 mutation subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ABCB1 mutation is associated with higher neurotoxicity of taxane\u2010based chemotherapy. It also predicts shorter PFS for NSCLC in paclitaxel\u2010based treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13184","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:45:01Z","timestamp":1569908701000},"page":"2088-2095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["ABCB1 polymorphism predicts the toxicity and clinical outcome of lung cancer patients with taxane\u2010based chemotherapy"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-3754","authenticated-orcid":false,"given":"Jia","family":"Zhong","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mancheng People's Hospital  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Deportment of Medical Oncology Dong'e People's Hospital  Liaocheng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mancheng People's Hospital  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongtong","family":"An","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meina","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-7791","authenticated-orcid":false,"given":"Minglei","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjie","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-1865","authenticated-orcid":false,"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Medical Oncology\u2010I Peking University Cancer Hospital &amp; 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