{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:49:43Z","timestamp":1747892983773,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Leiomyosarcoma with osteoclast\u2010like giant cells (LMS\u2010OGC) has seldom been reported clinically. LMS\u2010OGC of the breast is extremely rare according to the literature. Here, we report a case of LMS\u2010OGC leiomyosarcoma with osteoclast\u2010like giant cells of the breast. A 51\u2010year\u2010old female patient presented with a breast mass which was treated surgically and the pathological examination of the tumor indicated LMS\u2010OGC. Microscopically, the tumor was composed of spindle cells arranged in bundles or spokes with giant tumor cells and mitosis. Eosinophilic cytoplasm and morphologically benign osteoclast\u2010like cells were mixed together. Immunohistochemistry examination revealed SMA and desmin were positive with a Ki\u201067 proliferation index of 40%. However, CK (AE1\/AE3), E\u2010cadherin, ER, PR, CD34, S\u2010100 and CD10 were negatively expressed in the tumor tissue. LMS\u2010OGC is a soft tissue malignant tumor which develops extremely rarely in the breast. It should be differentiated and diagnosed according to the history, histological characteristics and immunohistochemical staining.<\/jats:p>","DOI":"10.1111\/1759-7714.13190","type":"journal-article","created":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T23:54:05Z","timestamp":1567382045000},"page":"2054-2056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leiomyosarcoma with osteoclast\u2010like (LMS\u2010OGC) giant cells the breast: A report of a rare case"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6595-9632","authenticated-orcid":false,"given":"Zhonghai","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology, Kingmed Diagnostics  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathology Traditional Chinese Medicine Hospital of Dafeng City  Yancheng Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kingmed Diagnostics  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanjiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kingmed Diagnostics  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Emergency Zhuji People's Hospital of Zhejiang Province  Zhuji Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2<495::AID-CNCR2820360228>3.0.CO;2-I"},{"key":"e_1_2_6_3_1","first-page":"510","article-title":"Leiomyosarcoma with osteoclast\u2010like giant cells of the uterus: A case report and literature review","volume":"93","author":"Sukpan K","year":"2010","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.11.010"},{"key":"e_1_2_6_5_1","first-page":"25","article-title":"Clinical aspects and pathology of malignant fibrous histiocytoma","volume":"33","author":"Z\u00f6ller J","year":"1988","journal-title":"Fortschr Kiefer Gesichtschir"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.896266"},{"key":"e_1_2_6_7_1","first-page":"30","article-title":"Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast\u2010like giant cells: A case report","volume":"8","author":"Sasaki T","year":"2018","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_6_8_1","first-page":"896","article-title":"Leiomyosarcoma of the cervix uteri with osteoclast\u2010like giant cells","volume":"90","author":"Ben SR","year":"2012","journal-title":"Tunis Med"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:30:53Z","timestamp":1694287853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/1759-7714.13190"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13190","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}