{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:33:14Z","timestamp":1783114394019,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have documented the therapeutic value of computed tomography (CT)\u2010guided percutaneous microwave ablation (MWA) for early\u2010stage non\u2010small cell lung cancer (NSCLC). However, few studies have focused on patients aged 80\u2009years and older. This retrospective study aimed to evaluate the safety and clinical outcomes of CT\u2010guided percutaneous MWA in patients aged 80\u2009years and older with early\u2010stage peripheral NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 63 patients aged 80\u2009years and older with cT1a\u20102bN0M0 peripheral NSCLC who underwent CT\u2010guided percutaneous MWA was performed between January 2008 and January 2018 at 11 hospitals in Shandong Province, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 21.0 months. The overall median survival time was 50\u2009months. The cancer\u2010specific median survival time was not reached in five years. The one\u2010, two\u2010, three\u2010, four\u2010, and five\u2010year overall survival rates were 97.1%, 92.6%, 63.4%, 54.4%, and 32.6%, respectively. The one\u2010, two\u2010, and three\u2010year cancer\u2010specific survival (CSS) rates were 97.9%, 97.9%, and 69.4%, respectively. The four\u2010 and five\u2010year CSS rates were not achieved. A total of 14 patients (22.2%) had local progression. The one\u2010, two\u2010, three\u2010, four\u2010, and five\u2010year local control rates were 88.8%, 78.8%, 70.3%, 63.9%, and 63.9%, respectively. The mortality rate was 0% within 30\u2009days after the procedure. Major complications included pneumothorax requiring drainage (21.1%), pulmonary infection (4.2%), and pleural effusions requiring drainage (2.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT\u2010guided percutaneous MWA is a safe and effective modality for treating patients aged 80\u2009years and older with early\u2010stage peripheral NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13209","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:38:50Z","timestamp":1572827930000},"page":"2236-2242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Safety and clinical outcomes of computed tomography\u2010guided percutaneous microwave ablation in patients aged 80\u2009years and older with early\u2010stage non\u2010small cell lung cancer: A multicenter retrospective 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