{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:39:12Z","timestamp":1787243952238,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The status of axillary lymph nodes (ALNs) is one of the important factors in decision\u2010making for breast cancer treatment. Physical examination (PE) has long been the main, or even the only, means of clinical staging for ALNs in breast cancer. However, the sensitivity and accuracy of PE remains unsatisfactory. The results from this study suggest that axillary ultrasonography (US) should replace PE as a standard method for the clinical staging of ALNs in breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive and nonselective breast cancer patients treated between September 2018 and November 2018 in our center were enrolled in the study. Comparisons of ALN results between PE\/US and pathological results were conducted and the difference in sensitivity, specificity and accuracy between PE and US were tested by McNemar chi\u2010square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 123 patients were enrolled into the study. Their ages ranged from 28 to 76\u2009years with a median age of 53\u2009\u00b1\u200910. There were 83 ALN positive cases and 40 ALN negative cases confirmed pathologically. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PE and US were 54.2%, 90.0%, 65.9%, 91.8%, 48.7% versus 86.8%, 72.5%, 82.1%, 86.8%, 72.5%, respectively. The sensitivity and accuracy of US was significantly higher than that of PE (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.004 and\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study demonstrated that US is superior in evaluating ALNs when compared with PE and that US should replace PE as the standard method for the clinical staging of ALNs in breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.13224","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T20:15:05Z","timestamp":1573503305000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ultrasound as a replacement for physical examination in clinical staging of axillary lymph nodes in breast cancer patients"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-6381","authenticated-orcid":false,"given":"Xue","family":"Chen","sequence":"first","affiliation":[{"name":"Breast Cancer Prevention &amp; Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqing","family":"Fan","sequence":"additional","affiliation":[{"name":"Breast Cancer Prevention &amp; Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Breast Cancer Prevention &amp; Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Xie","sequence":"additional","affiliation":[{"name":"Breast Cancer Prevention &amp; Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Cancer Prevention &amp; Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Breast Cancer Prevention &amp; Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"169","article-title":"Clinical evaluation of axillar lymph nodes compared to surgical and pathological findings","volume":"12","author":"Sacre RA","year":"1986","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0936"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601290"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00748-7"},{"issue":"10","key":"e_1_2_7_6_1","first-page":"672","article-title":"Morphology\u2010based criteria for ultrasonic assessment of axillary lymph node status in primary breast cancer","volume":"92","author":"Huo L","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3280-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4591-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1606"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1788-5"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"557","article-title":"I. 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