{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:14:19Z","timestamp":1782738859269,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Primary germ cell tumors of the mediastinum are rare neoplasms. Above all, choriocarcinomas are highly aggressive with early haematogenous dissemination. Here, we report an extremely rare case of mixed\u2010type primary germ cell tumor of the mediastinum which occurred in a 26\u2010year\u2010old man with multiple metastases of the lung caused by choriocarcinoma components, with diffuse pulmonary hemorrhaging. The patient developed a sudden life threatening condition a few days after a needle biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:bold>Significant findings of the study<\/jats:bold>: This was an extremely rare case of mixed\u2010type germ cell tumor in a young adult male who developed a sudden life threatening condition due to choriocarcinoma components just a few days after a needle biopsy.<\/jats:p><jats:p><jats:bold>What this study adds<\/jats:bold>: Serious conditions may occur in patients with germ cell tumor containing choriocarcinoma components. At present, there is no other way to treat such patients than to promptly recognize complications and perform urgent multimodal intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13231","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T11:36:40Z","timestamp":1573040200000},"page":"166-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mixed\u2010type primary germ cell tumor of the mediastinum in a young adult male with a sudden life threatening condition: A case report"],"prefix":"10.1111","volume":"11","author":[{"given":"Tadashi","family":"Sakane","sequence":"first","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya 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