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Among cancer patients, less than 1% overall develop PNS. Anti\u2010SOX1 antibodies' positive paraneoplastic neurological disorders are rare and are usually associated with small cell lung cancer (SCLC). Here, we report a case of a 61\u2010year\u2010old male patient who presented with an unusual anti\u2010SOX1 positive PNS. The right tibialis anterior showed noticeable low\u2010amplitude motor unit potentials and high amplitude motor potentials in electrodiagnostic study, suggesting the presence of Lambert\u2010Eaton myasthenic syndrome (LEMS). Typical MRI and PET\u2010CT found a hyperintense lesion with contrast enhancement in the thorax in front of 5\u20136 centrum of vertebrae, and thoracoscopic biopsy revealed pathological findings for SCLC. The patient underwent several lines of chemotherapy and radiotherapy and survived for 15\u2009months after the diagnosis of SCLC.<\/jats:p>","DOI":"10.1111\/1759-7714.13290","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T10:47:35Z","timestamp":1577443655000},"page":"465-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010SOX1 antibody\u2010positive paraneoplastic neurological syndrome presenting with Lambert\u2010Eaton myasthenic syndrome and small cell lung cancer: A case report"],"prefix":"10.1111","volume":"11","author":[{"given":"Chunyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Inner Mongolia Medical University  Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated 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