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S\u20101 plus cisplatin with concurrent radiotherapy is a commonly used treatment for other malignancies, including non\u2010small cell lung cancer (NSCLC). In addition, its safety has been confirmed, and it has been reported to have a marked effect against thymic carcinoma. Therefore, we conducted a phase II study of S\u20101 plus cisplatin with concurrent thoracic radiotherapy for locally advanced thymic carcinoma, in which the overall response rate was employed as the primary endpoint. The secondary endpoints were overall survival, progression\u2010free survival, and safety.<\/jats:p>","DOI":"10.1111\/1759-7714.13319","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T09:22:04Z","timestamp":1580894524000},"page":"693-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["S\u20101 plus cisplatin with concurrent radiotherapy for locally advanced thymic carcinoma: Study protocol of LOGIK1605\/JART\u20101501"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-1843","authenticated-orcid":false,"given":"Minoru","family":"Fukuda","sequence":"first","affiliation":[{"name":"Clinical Oncology Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Funaki","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Sato","sequence":"additional","affiliation":[{"name":"Clinical Research Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Takenoyama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology National Hospital Organization Kyusyu Cancer Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Nabeshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tateyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Kasugai Municipal Hospital  Kasugai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Ashizawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya City West Medical Center  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Seto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology National Hospital Organization Kyusyu Cancer Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinoshin","family":"Okumura","sequence":"additional","affiliation":[{"name":"Osaka Toneyama Medical Center  Osaka Japan"},{"name":"Japanese Association for Research on the Thymus (JART)  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sugio","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Oita Japan"},{"name":"Lung Oncology Group in Kyusyu (LOGiK)  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2003.09.022"},{"key":"e_1_2_6_3_1","first-page":"2602","article-title":"Antitumor activity of 1 M tegafur\u20100.4 M 5\u2010chloro\u20102,4\u2010dihydroxypyridine\u20101 M potassium oxonate (S\u20101) against human colon carcinoma orthotopically implanted into nude rats","volume":"56","author":"Shirasaka T","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2031"},{"key":"e_1_2_6_5_1","first-page":"653","article-title":"Clinical implications of immunoreactivity of thymidylate synthase and dihydropyrimidine dehydrogenase in gastric cancer treated with oral fluoropyrimidine (S\u20101). 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