{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:06:37Z","timestamp":1791911197783,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701216"],"award-info":[{"award-number":["31701216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017MC008"],"award-info":[{"award-number":["ZR2017MC008"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Mucociliary epithelium lining the upper and lower respiratory tract constitutes the first line of defense of the airway and lungs against inhaled pollutants and pathogens. The concerted beating of multiciliated cells drives mucociliary clearance. Abnormalities in both the structure and function of airway cilia have been implicated in obstructive lung diseases. Emerging evidence reveals a close correlation between lung diseases and environmental stimuli such as sulfur dioxide and tobacco particles. However, the underlying mechanism remains to be described. In this review, we emphasize the importance of airway cilia in mucociliary clearance and discuss how environmental pollutants affect the structure and function of airway cilia, thus shedding light on the function of airway cilia in preventing obstructive lung diseases and revealing the negative effects of environmental pollutants on human health.<\/jats:p>","DOI":"10.1111\/1759-7714.13323","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T03:32:14Z","timestamp":1579836734000},"page":"505-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Environmental pollutants damage airway epithelial cell cilia: Implications for the prevention of obstructive lung diseases"],"prefix":"10.1111","volume":"11","author":[{"given":"Yu","family":"Cao","sequence":"first","affiliation":[{"name":"College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-6948","authenticated-orcid":false,"given":"Songbo","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-7100","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490805"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpsc.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071931"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0304OC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129704"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0272-5231(21)00590-6","article-title":"Immotile cilia syndrome (primary ciliary dyskinesia) and inflammatory lung disease","volume":"9","author":"Rubin BK","year":"1988","journal-title":"Clin Chest Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2017.06.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0053-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12890"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12974"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells5040040"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101146"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/s90907003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-019-0100-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.136"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0114-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12284"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00720"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01337"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2014.00702"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.12137"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12374-014-0330-8"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.3.726"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/1543060"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/MPUL.2017.2746243"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12630"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12792"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12579"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12491"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00403103"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201802-128AW"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13e39.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.16.00078"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-011-9744-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.164178"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2016.02.017"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.04.069"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298668191419361"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02325.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2016.1260539"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1078\/1434-4610-00073"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10962247.2016.1265026"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-4"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac503214v"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200907080"},{"key":"e_1_2_8_47_1","first-page":"1651","article-title":"Differences in airway reactivity in normal and allergic sheep after exposure to sulfur dioxide","volume":"51","author":"Abraham WM","year":"1981","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2012.03.001"},{"key":"e_1_2_8_49_1","first-page":"1","article-title":"Altered susceptibility to viral respiratory infection during short\u2010term exposure to nitrogen dioxide","volume":"24","author":"Rose RM","year":"1989","journal-title":"Res Rep Health Eff Inst"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08101664"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.2.9711068"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01209"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/1442-1984.12132"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191406"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2004.09.009"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2017.0540"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jea.7500284"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136415"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80206-4"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418811324"},{"key":"e_1_2_8_61_1","first-page":"64","article-title":"Nasal cilia in normal man, primary ciliary dyskinesia and other respiratory diseases: Analysis of motility and ultrastructure","volume":"127","author":"Rossman CM","year":"1983","journal-title":"Eur J Respir Dis Suppl"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.13323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:03:46Z","timestamp":1694009026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/1759-7714.13323"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13323","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"assertion":[{"value":"2019-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}