{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:06:29Z","timestamp":1790024789788,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T00:00:00Z","timestamp":1582329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate the prognostic value of baseline hemoglobin\u2010to\u2010red blood cell distribution width ratio (HRR) in patients with small cell lung cancer (SCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the medical records of patients with newly diagnosed SCLC who had received first\u2010line chemotherapy at the Department of Pulmonary Oncology of the PLA 307 Hospital between January 2008 and October 2018. The optimal cutoff value of the continuous variables was determined using the X\u2010tile software. Univariate and multivariate analyses were conducted using Cox proportional hazard models. The Kaplan\u2010Meier method was used for survival analysis, with differences tested using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 146 patients were included. The cutoff value for HRR was determined as 0.985. Statistically significant differences were observed in sex, smoking history, stage, radiotherapy combination, neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, hemoglobin, and red blood cell distribution width between the high and low HRR groups. The median overall survival (OS) was nine and 17.5 months in the low and high HRR groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The median progression\u2010free survival (PFS) was five and 8.5 months, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Univariate and multivariate analyses showed low HRR to be an independent predictor of a poor prognosis for OS (hazard ratio = 3.782; 95% confidence interval, 2.151\u20136.652;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and PFS (hazard ratio = 2.112; 95% confidence interval, 1.195\u20133.733;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01) in SCLC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low HRR was associated with poorer OS and PFS in patients with SCLC and can be a potentially valuable prognostic factor for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>The prognostic value of the baseline hemoglobin\u2010to\u2010red blood cell distribution width ratio was evaluated in patients with small cell lung cancer.<\/jats:p>\n                    <jats:p>In this population, this ratio was an independent predictor of overall survival and progression\u2010free survival. This ratio, an inexpensive and routine parameter, can be used as a prognostic factor in small cell lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.13330","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T17:41:26Z","timestamp":1582393286000},"page":"888-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Prognostic value of baseline hemoglobin\u2010to\u2010red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis"],"prefix":"10.1111","volume":"11","author":[{"given":"Fangfang","family":"Wu","sequence":"first","affiliation":[{"name":"PLA 307 Clinical College Anhui Medical University  Beijing China"},{"name":"Department of Pulmonary Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-4848","authenticated-orcid":false,"given":"Wenjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-4292","authenticated-orcid":false,"given":"Hongjun","family":"Gao","sequence":"additional","affiliation":[{"name":"PLA 307 Clinical College Anhui Medical University  Beijing China"},{"name":"Department of Pulmonary Oncology The Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318286cf88"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2004.10.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.29319"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442949"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00508-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1447"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21729"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz122"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000120)89:1<81::AID-IJC13>3.0.CO;2-I"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.11.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19572-y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7606128"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0806-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.08.032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11144-w"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.07.024"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.5858\/134.4.505.c","article-title":"Relation between red blood cell distribution width and inflammatory biomarkers in rheumatoid arthritis","volume":"134","author":"Lee WS","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_21_1","first-page":"121","article-title":"Salemis NS. 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