{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:22:38Z","timestamp":1782879758617,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFC0113501"],"award-info":[{"award-number":["2017YFC0113501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The ProCore 25\u2010gauge needle is a novel specifically designed puncture needle for endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA), which may improve the puncture efficiency of the procedure while ensuring the diagnostic rate. The aim of the present study was to evaluate the diagnostic accuracy, mRNA yield, and complication rate of 25\u2010gauge needles compared to those of 22\u2010gauge needles in the evaluation of mediastinal and hilar lymphadenopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 39 patients undergoing EBUS\u2010TBNA at our institution were evaluated. All the procedures were performed by an experienced endoscopist formally trained in interventional pulmonology. Both the traditional 22\u2010gauge and ProCore 25\u2010gauge needles were used at each lymph node station. For all specimens obtained via EBUS\u2010TBNA, 50\u2009\u03bcL was used to extract mRNA and detect the RNA concentration, whereas the other part was sent to the pathological evaluation. \u03c7<jats:sup>2<\/jats:sup> test and <jats:italic>t<\/jats:italic>\u2010test were performed to determine the differences between the two types of the needles. A <jats:italic>P<\/jats:italic>\u2010value of &lt;0.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 88 lymph nodes were punctured by the two needles separately. The diagnostic accuracy for each puncture between the two needles did not show any significant difference (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). No serious procedure\u2010related complications were reported. In addition, the mRNA concentration did not differ between the two types of needles (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ProCore 25\u2010gauge needle gained a similar diagnostic yield with less puncture time and frequency compared with the 22\u2010gauge needle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13332","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T08:30:23Z","timestamp":1580200223000},"page":"748-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Novel ProCore 25\u2010gauge needle for endobronchial ultrasound\u2010guided transbronchial needle aspiration reduces the puncture time and frequency, with comparable diagnostic rate for mediastinal and hilar lymphadenopathy"],"prefix":"10.1111","volume":"11","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Endoscopy Center, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gu","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yu","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 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