{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:19:22Z","timestamp":1778692762078,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Granulomatous dermatitis (GD) is the most common among a variety of skin reactions that may occur in the varicella\u2010zoster virus (VZV) reactivation area. It is thought that the formation of granulomas may be the result of a delayed hypersensitivity reaction to viral envelope glycoproteins. Immune checkpoint inhibitors (ICIs), such as nivolumab stimulate T cells and promote hypersensitivity reactions, leading to the formation of granulomas in VZV wrapping proteins, thus triggering VZV\u2010GD. Few cases of the use of ICIs in patients diagnosed with VZV\u2010GD have been reported in the literature. Here, we report the clinical case of a patient with metastatic lung cancer which was treated with nivolumab who subsequently developed VZV\u2010GD. Accurate clinical diagnosis and prompt treatment with antiviral agents have resulted in a complete resolution of the clinical picture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:sec><jats:title>Significant findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Treatment with ICIs may result in VZV reactivation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Accurate differential diagnosis and early treatment led to the resolution of VZV\u2010GD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><\/jats:sec><jats:sec><jats:title>What this study adds<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Few cases of ICI and VZV reactivation have been reported in the literature.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Full and timely resolution of VZV\u2010GD allowed the continuation of ICI treatment.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13377","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:39:45Z","timestamp":1583455185000},"page":"1330-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report"],"prefix":"10.1111","volume":"11","author":[{"given":"Elisa","family":"Gozzi","sequence":"first","affiliation":[{"name":"UOC of Oncology \u2010 ASL Latina\u2010 Distretto 1 University of Rome \u201cSapienza,\u201d via Giustiniano snc \u2013 04011  Aprilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-6780","authenticated-orcid":false,"given":"Luigi","family":"Rossi","sequence":"additional","affiliation":[{"name":"UOC of Oncology \u2010 ASL Latina\u2010 Distretto 1 University of Rome \u201cSapienza,\u201d via Giustiniano snc \u2013 04011  Aprilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Angelini","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Regina Apostolorum Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Leoni","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Regina Apostolorum Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Trenta","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Regina Apostolorum Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cimino","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sapienza University of Rome, Medical and Surgical Sciences and Biotechnology  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silverio","family":"Tomao","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology A, Policlinico Umberto I Sapienza University of Rome  Rome Italy"},{"name":"Consorzio Interuniversitario per la Bio\u2010Oncologia (CINBO)  Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"issue":"8","key":"e_1_2_5_2_1","first-page":"783","article-title":"Post\u2010herpetic granulomatous dermatitis in a man treated with Nivolumab","volume":"108","author":"Mart\u00edn\u2010Carrasco P","year":"2017","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","unstructured":"AssiT DanuA MateusCet al.Post\u2010shingles granulomatous dermatosis related to anti\u2010programmed cell death 1.Immunotherapy.2019;11(7):591\u20138.https:\/\/doi.org\/10.2217\/imt-2018-0169.","DOI":"10.2217\/imt-2018-0169"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.02.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1302674"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6987"},{"key":"e_1_2_5_7_1","unstructured":"Official Nivolumab EMA data sheet. Available from URL:https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/opdivo-epar-product-information_it.pdf."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12531"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx225"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.13377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:32:29Z","timestamp":1756204349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/1759-7714.13377"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13377","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,5]]},"assertion":[{"value":"2019-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}