{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:41:51Z","timestamp":1792608111178,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31770961"],"award-info":[{"award-number":["31770961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Lambert\u2010Eaton myasthenic syndrome (LEMS) is a rare disease characterized by involvement of the neuromuscular junction. Most cases have an underlying malignancy, especially small\u2010cell lung cancer (SCLC), while adenocarcinoma is less common. Here, we report a rare case of metastatic lung adenocarcinoma complicated with LEMS. In this case, L858R mutation was detected in the 21st exon of the <jats:italic>EGFR<\/jats:italic> gene. First\u2010line treatment with gefitinib was given, and the patient has survived for more than six years. Early diagnosis of LEMS and timely and effective treatment can result in a good prognosis. We also searched for \u201clung cancer\u201d, or \u201ccarcinoma of lung\u201d, or \u201cadenocarcinoma of lung\u201d, or \u201cLambert\u2010Eaton myasthenic syndrome\u201d in PubMed until 1 December 2019. Seven cases of lung adenocarcinoma complicated with LEMS were found, most of which had a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p>This article reports a rare case of metastatic lung adenocarcinoma with <jats:italic>EGFR<\/jats:italic> mutation, complicated with LEMS. Gefitinib was given as first\u2010line treatment, and resulted in a good prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13385","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T08:55:23Z","timestamp":1583830523000},"page":"1334-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful treatment of advanced lung adenocarcinoma complicated with Lambert\u2010Eaton myasthenic syndrome: A case report and literature review"],"prefix":"10.1111","volume":"11","author":[{"given":"Aili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis Shijiazhuang Fifth Hospital  Hebei 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