{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:35:58Z","timestamp":1780922158243,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Xinjiang Uygur Autonomous Region","award":["201517103"],"award-info":[{"award-number":["201517103"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pneumonia is a common acute lower respiratory infection in children and elders. Circular RNAs (circRNAs) have recently been uncovered to play important roles in pneumonia. However, the function and mechanism of circ_0038467 in pneumonia remain elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cell viability and apoptosis were determined using the Cell Counting Kit\u20108 (CCK\u20108) assay and flow cytometry, respectively. The levels of interleukin 6 (IL\u20106), IL\u20108 and IL\u20101\u03b2 were detected by enzyme\u2010linked immunosorbent assay (ELISA). Western blot analysis was performed to assess the expression of related proteins. Circ_0038467 was characterized by Ribonuclease R (RNase) digestion and subcellular localization assays. The levels of circ_0038467 and miR\u2010338\u20103p were evaluated by quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR). The direct interaction between circ_0038467 and miR\u2010338\u20103p was validated by the dual\u2010luciferase reporter and RNA immunoprecipitation (RIP) assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data indicated that lipopolysaccharide (LPS) induced an inflammatory injury in 16HBE cells by repressing cell viability and enhancing cell apoptosis and proinflammatory cytokines production. Circ_0038467 was upregulated and miR\u2010338\u20103p was downregulated in LPS\u2010treated 16HBE cells. Circ_0038467 knockdown or miR\u2010338\u20103p overexpression attenuated LPS\u2010induced 16HBE cell inflammatory injury. Moreover, circ_0038467 acted as a sponge of miR\u2010338\u20103p in 16HBE cells. MiR\u2010338\u20103p mediated the alleviated effect of circ_0038467 knockdown on LPS\u2010induced 16HBE cell inflammatory injury. Additionally, the Janus kinase\/ signal transducer and activator of transcription 3 (JAK\/STAT3) signaling pathway was involved in the circ_0038467\/miR\u2010338\u20103p axis\u2010mediated regulation in LPS\u2010induced 16HBE cell inflammatory injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current work had led to the identification of circ_0038467 knockdown that alleviated LPS\u2010induced inflammatory injury in 16HBE cells at least partly through sponging miR\u2010338\u20103p and regulating JAK\/STAT3 pathway, highlighting novel molecular targets for the treatment of pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13397","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T10:24:34Z","timestamp":1584440674000},"page":"1297-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Circ_0038467 regulates lipopolysaccharide\u2010induced inflammatory injury in human bronchial epithelial cells through sponging miR\u2010338\u20103p"],"prefix":"10.1111","volume":"11","author":[{"given":"Guangming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory Intensive Care Unit The First Affiliated Hospital of Xinjiang Medical University, Urumqi  Xinjiang China"},{"name":"Department of Internal Medicine Tacheng Municipality People's Hospital  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiufeng","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Intensive Care Unit The First Affiliated Hospital of Xinjiang Medical University, Urumqi  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Intensive Care Unit The First Affiliated Hospital of Xinjiang Medical University, Urumqi  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Intensive Care Unit The First Affiliated Hospital of Xinjiang Medical University, Urumqi  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingli","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Intensive Care Unit The First Affiliated Hospital of Xinjiang Medical University, Urumqi  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-5677","authenticated-orcid":false,"given":"Sicheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Intensive Care Unit The First Affiliated Hospital of Xinjiang Medical University, Urumqi  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2018.07.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.06.003"},{"key":"e_1_2_7_6_1","unstructured":"DimmelerS NicolasJ BoeckelNet al. 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