{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:43:08Z","timestamp":1789746188461,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Several studies have demonstrated increased pericardial effusion during anti\u2010PD\u20101 immunotherapy, and treatment in patients who have developed pericardial tamponade is controversial. In this study, we describe a 63\u2010year\u2010old woman with stage IVA lung adenocarcinoma given pembrolizumab as a first\u2010line therapy. After four cycles of pembrolizumab treatment, the patient suddenly developed a pericardial tamponade. Although pericardial effusion was increased, her tumor lesions were reduced. After an emergency pericardiocentesis, she continued the pembrolizumab therapy without recurrent pericardial effusions for three months until the primary tumor and lymph node metastasis progressed. Nine months after the pericardiocentesis, the patient died of progressive lung cancer, but pericardial effusion did not recur throughout the treatment course. This case study suggests that pembrolizumab therapy can be continued with a strict follow\u2010up in some patients with pembrolizumab\u2010induced pericardial tamponade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p>\u2022 <jats:bold>Significant findings of the study<\/jats:bold><\/jats:p><jats:p>Our patient developed pericardial tamponade during pembrolizumab treatment but continued pembrolizumab treatment after emergency pericardiocentesis without recurrent pericardial effusions.<\/jats:p><jats:p>\u2022 <jats:bold>What this study adds<\/jats:bold><\/jats:p><jats:p>Pembrolizumab treatments may be resumed with a strict follow\u2010up in some patients with treatment\u2010related pericardial tamponade.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13399","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T09:36:09Z","timestamp":1584437769000},"page":"1350-1353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pericardial tamponade during pembrolizumab treatment in a patient with advanced lung adenocarcinoma: A case report and review of the literature"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-1884","authenticated-orcid":false,"given":"Kazuaki","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Kushiro Rosai Hospital  Kushiro Japan"},{"name":"Department of Internal Medicine Kushiro Rosai Hospital  Kushiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular 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