{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:20:11Z","timestamp":1780950011251,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although the use of radial endobronchial ultrasound (R\u2010EBUS) with a guide sheath has shown improved diagnostic capability in peripheral pulmonary lesions, its utility is still low due to variable performance. To overcome its limitation, we evaluated the feasibility and efficacy of R\u2010EBUS combined with transbronchial biopsy (TBB) under fluoroscopic guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed medical records of 74 patients with non\u2010small cell lung cancer (NSCLC) who underwent R\u2010EBUS combined with TBB or TBB alone as a diagnostic technique. Subjects were grouped according to the diagnostic modality used (R\u2010EBUS combined with TBB vs. TBB alone). Each group was matched for age, sex, and location of the biopsy. The chi\u2010square test and paired <jats:italic>t<\/jats:italic>\u2010test were used to compare characteristics and identify factors that affected the diagnostic yield.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the study cohort was 67.4\u2009\u00b1\u200912.8\u2009years, with 21 (56.8%) men and 16 (43.2%) women in each group. The lesion size was significantly smaller in the R\u2010EBUS group (23.6 vs. 33.9, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The diagnostic yield with the combined use of R\u2010EBUS and TBB (27\/37, 72.9%) was significantly higher than that with standard TBB alone (22\/37, 59.4%). Lung lesions with a positive bronchus sign were associated with a higher diagnostic yield (odds ratio = 3.52 [1.17\u201310.62]; <jats:italic>P<\/jats:italic> = 0.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of R\u2010EBUS with TBB resulted in a higher diagnostic yield than either technique alone. Thus, the addition of R\u2010EBUS biopsy would be helpful to improve the diagnostic yield of TBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><\/jats:sec><jats:sec><jats:title>Significant findings of the study<\/jats:title><jats:p>The combination of R\u2010EBUS with TBB under fluoroscopic guidance improved the diagnostic yield of PPLs compared to TBB alone. A tissue diagnosis was more likely in pulmonary lesions with the air\u2010bronchus sign.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this study adds<\/jats:title><jats:p>The use of R\u2010EBUS could help improve the low diagnostic yield of TBB under fluoroscopic guidance without increasing the incidence of complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13425","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T03:01:19Z","timestamp":1587092479000},"page":"1533-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic value of the combined use of radial probe endobronchial ultrasound and transbronchial biopsy in lung cancer"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-6804","authenticated-orcid":false,"given":"Sang Chul","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine National Health Insurance Corporation Ilsan Hospital  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hoon","family":"Han*","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine National Health Insurance Corporation Ilsan Hospital  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.05.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.03.11"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0990OC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0062"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.76.2.176"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-287-916-5_1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200612-1866OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.11.073"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2353"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e31823fcf11"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12980"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142336"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3.959"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00075310"},{"issue":"4","key":"e_1_2_7_18_1","first-page":"596","article-title":"Endobronchial ultrasound with a guide sheath for small malignant pulmonary nodules: A retrospective comparison between central and peripheral locations","volume":"7","author":"Chavez C","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2506"},{"issue":"11","key":"e_1_2_7_20_1","first-page":"1469","article-title":"Radiation dose to patients and clinicians during fluoroscopically\u2010guided biopsy of peripheral pulmonary lesions","volume":"55","author":"Steinfort DP","year":"2010","journal-title":"Respir Care"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1764"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","unstructured":"TannerNT YarmusL ChenA.et al.Standard bronchoscopy with fluoroscopy vs thin bronchoscopy and radial endobronchial ultrasound for biopsy of pulmonary lesions: A multicenter prospective randomized trial.Chest2018;154(5):1035\u201343.","DOI":"10.1016\/j.chest.2018.08.1026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2018.0073"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1234"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179719"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(05)80197-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431383"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201711-856OC"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.4.1185"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0704-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2014.03.014"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.13425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:35:09Z","timestamp":1693971309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/1759-7714.13425"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13425","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]},"assertion":[{"value":"2019-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}