{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:53:45Z","timestamp":1764251625182,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0901500"],"award-info":[{"award-number":["2016YFC0901500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>A 49\u2010year\u2010old man presented to our outpatient clinic complaining of nonproductive cough and exertional dyspnea for two\u2009months. He had been diagnosed with large B cell non\u2010Hodgkin's lymphoma seven\u2009months previously, and the tumor had almost disappeared after four\u2009cycles of rituximab\u2010containing chemotherapy. He then developed a severe dry cough, progressive dyspnea and hypoxia two\u2009weeks after the fifth cycle. Bilateral diffuse ground\u2010glass opacities were visible on chest X\u2010ray. Although the patient's symptoms were ameliorated temporarily after two\u2009weeks of methylprednisolone administration and multiple antibiotics, exertional dyspnea had progressed slowly starting one month after discontinuation of the corticosteroid. A repeat chest computed tomography (CT) scan showed diffuse ground\u2010glass opacities, bronchoalveolar lavage fluid tests for pathogens were negative and the pathological manifestation of the transbronchial lung biopsy showed nonspecific interstitial pneumonia. Rituximab\u2010induced interstitial lung disease was diagnosed after multidisciplinary discussion. Prednisone was again prescribed and his symptoms and the pulmonary opacities gradually disappeared. Although various pulmonary infections are the most common respiratory complications in patients with non\u2010Hodgkin's lymphoma undergoing rituximab\u2010containing chemotherapy, noninfectious diffuse lung disease, eg, drug\u2010associated interstitial lung disease might be considered as a differential diagnosis of patients treated with rituximab, especially if a patient is nearing the time of administration of a fourth cycle of rituximab.<\/jats:p>","DOI":"10.1111\/1759-7714.13473","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T15:39:28Z","timestamp":1588779568000},"page":"2040-2043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progressive dyspnea and diffuse ground\u2010glass opacities after treatment for lymphoma with rituximab\u2010containing chemotherapy: A case report"],"prefix":"10.1111","volume":"11","author":[{"given":"Yuxin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Radiological Department Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Pathological Department Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"International Medical Service Department Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; 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