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Total excision on initial surgery is an established indicator of a positive outcome. Here, we report the case of a 52\u2010year\u2010old man who was admitted to our hospital with symptoms of cough, chest pain, and dyspnea for two\u2009months. Chest computed tomography (CT) scan revealed a middle mediastinal mass which infiltrated adjacent vital structures, and surgery was performed with the assistance of cardiopulmonary bypass (CPB) and median sternotomy. The mass was completely removed and histopathology confirmed the presence of a mesenchymal tumor. The patient had an uneventful recovery without any perioperative symptoms, hoarseness, or dysfunction of the diaphragm. Sixty\u2010nine months after surgery, a CT scan confirmed that the patient remained disease\u2010free without necessitating the introduction of chemotherapy or radiotherapy. Here, to the best of our knowledge, we report the first case of a giant invasive mediastinal SFT that was completely resected during initial surgery under CPB with a remarkable outcome.<\/jats:p>","DOI":"10.1111\/1759-7714.13477","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T13:19:52Z","timestamp":1588857592000},"page":"2048-2050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Strategy for initial en bloc resection of a giant mediastinal solitary fibrous tumor: Judicious usage of cardiopulmonary bypass"],"prefix":"10.1111","volume":"11","author":[{"given":"Lei","family":"Chen","sequence":"first","affiliation":[{"name":"Cardiothoracic Surgery The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghua","family":"Sang","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery The 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