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This study was conducted to determine the diagnostic value of EBUS\u2010TBLB combined with FDG\u2010PET in the assessment of PPLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of 76 patients with PPLs who received both FDG\u2010PET and EBUS\u2010TBLB from January 2016 to February 2018 were retrospectively evaluated. Further subgroup analysis was performed according to lesion diameter (\u226420\u2009mm or &gt;20\u2009mm). Related diagnostic indices were calculated and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When combining EBUS\u2010TBLB with FDG\u2010PET, the diagnostic accuracy rate, sensitivity, specificity, Youden's index, positive predictive value, and negative predictive value for PPLs were 86.8%, 90.2%, 73.3%, 63.5%, 93.2%, and 64.7%, respectively. In addition, the diagnostic accuracy rate of the combined approach was significantly higher than the single EBUS\u2010TBLB and FDG\u2010PET (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, respectively), and its Youden's index was also at a higher level. When stratified by lesion diameter, the combined approach showed a significantly higher diagnostic accuracy rate (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and a higher Youden's index for PPLs &gt;20\u2009mm than PPLs \u226420\u2009mm. In addition, we found that positive bronchus sign and probe within the probe were two important factors conducing to enhancing the diagnostic accuracy rate for EBUS\u2010TBLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An integrated approach combining EBUS\u2010TBLB with FDG\u2010PET is particularly useful for diagnosing PPLs, and the improved diagnostic yields were especially evident for PPLs &gt;20\u2009mm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13484","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T11:23:23Z","timestamp":1592306603000},"page":"2094-2100","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated strategy combining endobronchial ultrasound with positron emission tomography to diagnose peripheral pulmonary lesions"],"prefix":"10.1111","volume":"11","author":[{"given":"Xiao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"An","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Zhao","sequence":"additional","affiliation":[{"name":"PET Center First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Dai","sequence":"additional","affiliation":[{"name":"Hospital Administration Office of Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Radisky","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology Mayo Clinic Cancer Center  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou 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