{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:19:50Z","timestamp":1778177990419,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"Abstract<\/jats:title>Schwannomas are homogeneous tumors of schwann cells and occur at peripheral and cranial nerves on the upper limbs, the head and neck area. Rarely, a bronchial schwannoma may appear in the lung and be misdiagnosed as lung neoplasms. Here, we report a 56\u2010year old woman with a 5.8\u2009\u00d7\u20097.0\u2009\u00d7\u20092.8 cm lesion in her right upper lobe bronchus. The lesion had a maximum standardized uptake value (SUVmax<\/jats:sub>) of 8.5 by 18\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET). Bronchoscopy showed a mass obstructing the bronchus that bled easily. Despite repeated biopsies, a lung malignancy could not be excluded, and surgical resection was subsequently performed. Pathological examination demonstrated a primary bronchial schwannoma that was positive for molecular markers S\u2010100 and SOX\u201010, negative for immune checkpoint marker PD\u20101\/PD\u2010L1 but also demonstrated certain uncommon pathological features. This case highlights the heterogeneity of bronchial masses and the diagnostic challenge for differentiating benign and malignant tumors in the thorax.<\/jats:p><\/jats:sec>Key points<\/jats:title>\nRare bronchial schwannoma mimics lung malignancy and poses a diagnostic challenge.<\/jats:p><\/jats:list-item>\nThis case of bronchial schwannoma, unlike peripheral schwannoma, lacks PD\u2010L1. Pathological features indicate autonomic nerve origin for pulmonary schwannomas.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13505","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T14:35:40Z","timestamp":1591626940000},"page":"2335-2338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["PD<\/scp>\u20101\/PD\u2010L1<\/scp> negative schwannoma mimicking obstructive bronchial malignancy: A case report"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-1470","authenticated-orcid":false,"given":"Daibing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology Huashan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Huashan Hospital, Fudan University Shanghai China"},{"name":"Department of Respiratory Medicine Huashan North Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Huashan Hospital, Fudan University Shanghai China"},{"name":"Department of Respiratory Medicine Huashan North Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12125"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.2.7839977"},{"key":"e_1_2_4_4_1","first-page":"305","article-title":"Tumors of the central nervous system in biopsy and autopsy material","volume":"127","author":"Schneider J","year":"1983","journal-title":"Zentralbl Allg 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