{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:49:28Z","timestamp":1776106168305,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate the risk factors of postoperative complications and reliable prognostic factors of long\u2010term survival in HIV\u2010infected patients with non\u2010small cell lung cancer (NSCLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HIV\u2010infected patients with NSCLC who underwent surgical treatment were retrospectively studied; a single\u2010institutional analysis was conducted from November 2011 to August 2018. Pre\u2010 and postoperative clinical data, including age, gender, smoking history, highly active antiretroviral therapy (HAART), CD4+ T cell count, HIV viral load, cancer histology, clinical and pathological stage (p\u2010stage), surgical result, Glasgow Prognostic Score (GPS), the Charlson comorbidity index (CCI), survival time and postoperative complications were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33 HIV\u2010infected patients with NSCLC were enrolled of which 18 (54.7%) had preoperative comorbidities and postoperative complications were observed in 22 (66.7%) patients. Thirty\u2010day mortality was not observed in these patients. Median survival time after surgery was 65\u2009months: the MST of p\u2010stage I patients was 65\u2009months; p\u2010stage II MST was unestimable; p\u2010stage III MST was 21\u2009months. Univariate analyses showed that postoperative complications were associated with HIV viral load (<jats:italic>P<\/jats:italic> = 0.002), CCI (<jats:italic>P<\/jats:italic> = 0.027), HAART (<jats:italic>P<\/jats:italic> = 0.028) and CD4+ T cell count (<jats:italic>P<\/jats:italic> = 0.045). However, multiple logistic regression analysis showed no correlation between HAART and postoperative complications. The p\u2010stage was an independent prognostic factor for survival time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our single\u2010arm retrospective analysis, the risk factors for postoperative complications in HIV\u2010infected patients with NSCLC were HIV viral load, CCI and CD4+ T cell counts. The p\u2010stage was a predictive factor for long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13519","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T03:29:38Z","timestamp":1594006178000},"page":"2146-2154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lung cancer surgery in <scp>HIV<\/scp>\u2010infected patients: An analysis of postoperative complications and long\u2010term survival"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5171-2663","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Public Health Clinical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanghai Public Health Clinical 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