{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:33Z","timestamp":1787013753468,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current study aimed to evaluate the serum pretreatment lactate dehydrogenase (LDH) and overall survival (OS) in small cell lung cancer (SCLC) patients who received first\u2010line platinum\u2010containing chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 234 SCLC patients, who received first\u2010line platinum\u2010based chemotherapy between 2013 and 2018, were retrospectively analyzed. The data of hematological characteristics, age, gender, ECOG score, staging, metastatic site, smoking history, chemotherapy cycle, thoracic radiotherapy and hyponatremia were collected. Overall survival was calculated using the Kaplan\u2010Meier method. The statistically significant factors in the univariate analysis were selected for the multivariate COX model analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age, ECOG score, stage, thoracic radiotherapy, hyponatremia, liver metastasis, brain metastasis, bone metastasis, LDH, NSE and neutrophil\u2010to\u2010lymphocyte ratio (NLR) were closely correlated to OS in the univariate analysis. Furthermore, the multivariate analysis revealed that age (&lt;65\u2009years), ECOG score (&lt;2 points), limited\u2010stage (LD), thoracic radiotherapy and LDH &lt;215.70 U\/L were the independent prognostic factors for survival. The median OS time was worse for patients with LDH \u2265215.70 U\/L. In the subgroup analysis, LDH \u2265215.70 U\/L was significant for survival in both limited and extensive disease. Patients who achieved CR\u2009+\u2009PR in the first\u2010line treatment had lower initial LDH levels. It was found that the pretreatment LDH increased the incidence of patients with liver metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Positive independent prognostic factors for SCLC patients were age\u2009&lt;\u200965\u2009years old, ECOG score\u2009&lt;\u20092 points, LD\u2010SCLC, and pretreatment LDH &lt;215.70 U\/L. These factors may be useful for stratifying patients with SCLC for treatment approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significant findings of the study<\/jats:title>\n                    <jats:p>Age\u2009&lt;\u200965\u2009years old, ECOG score\u2009&lt;\u20092 points, LD\u2010SCLC, and pretreatment LDH &lt;215.70 U\/L are the positive independent prognostic factors for SCLC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>What this study adds<\/jats:title>\n                    <jats:p>The current study provided more references for SCLC diagnosis and treatment and determined more factors for stratifying patients with SCLC for treatment approaches.<\/jats:p>\n                  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