{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T05:44:41Z","timestamp":1748151881665,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Programmed death\u2010ligand 1 (PD\u2010L1) is one of the immune checkpoint proteins, and plays an important role in the progression and microenvironment of cancer. PD\u2010L1 expression has been associated with poor survival in many cancers. Several studies have also shown an association between PD\u2010L1 expression and the prognosis of patients with thymic epithelial tumors (TETs). In this study, we systematically evaluated the prognostic and clinicopathological roles of PD\u2010L1 expression in TETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the literature through PubMed, Embase and Cochrane library and chose the eligible studies, and subsequently performed a meta\u2010analysis to evaluate the prognostic and clinicopathological roles of PD\u2010L1 expression in TETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of the 75 articles found in the literature were selected. PD\u2010L1 expression was significantly related to unfavorable overall survival (hazard ratio 1.52, 95% confidence interval [CI]: 1.01\u20132.30, <jats:italic>P<\/jats:italic> =\u20090.046) in TETs. PD\u2010L1 expression was significantly associated with male gender (odds ratio [OR] 1.55, 95% CI: 1.08\u20132.22, <jats:italic>P<\/jats:italic> =\u20090.017) and higher Masaoka stage (OR 3.93, 95% CI: 2.44\u20136.32, <jats:italic>P<\/jats:italic> &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PD\u2010L1 expression was correlated with unfavorable prognosis in TETs, indicating PD\u2010L1 expression could help determine the prognosis of TET patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13590","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:52:56Z","timestamp":1604364776000},"page":"3086-3098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic and clinicopathological roles of programmed death\u2010ligand 1 (<scp>PD\u2010L1<\/scp>) expression in thymic epithelial tumors: A meta\u2010analysis"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-7174","authenticated-orcid":false,"given":"Hyun Min","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Pathology Gyeongsang National University Changwon Hospital  Changwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Gun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology Jeju National University School of Medicine  Jeju Korea"},{"name":"Department of Pathology Jeju National University Hospital  Jeju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-5996","authenticated-orcid":false,"given":"Hyun Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Soonchunhyang University College of Medicine  Cheonan Korea"},{"name":"Department of Pathology Soonchunhyang University Cheonan Hospital  Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-1357","authenticated-orcid":false,"given":"Chang Lim","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Pathology Jeju National University School of Medicine  Jeju Korea"},{"name":"Department of Pathology Jeju National University Hospital  Jeju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01055"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.05.038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.09.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1943"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0588-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.555"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.08.037"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.10.044"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0316-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3216"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2019.04.24"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:28:08Z","timestamp":1693279688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/1759-7714.13590"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13590","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2020,9,14]]},"assertion":[{"value":"2020-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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