{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T19:29:57Z","timestamp":1748892597630,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261201700047C"],"award-info":[{"award-number":["HHSN261201700047C"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate oral leukoplakia (OL) and risk of upper gastrointestinal (UGI) cancer deaths in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3318 subjects with esophageal squamous dysplasia enrolled on 1 May 1985, and were followed up until 30 September 2015. Participants with OL at baseline were treated as an exposed group, while the remainder was selected as a control group. All subjects were followed monthly and reviewed quarterly by the Linxian Cancer Registry. Cox proportional hazard model was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 30\u2010year follow\u2010up, a total of 902 UGI cancer deaths occurred, including 541 esophageal squamous cell carcinoma (ESCC) related, 284 gastric cardia carcinoma (GCC) related, and 77 gastric noncardia carcinoma (GNCC) related deaths. Relative to subjects without OL, the long\u2010term risk of ESCC mortality in participants with OL increased by 26.1% (HR = 1.26, 95% CI: 1.05\u20131.52). In the subgroup analyses, adverse effects of OL on ESCC mortality were observed especially in younger subjects (HR = 1.48, 95% CI: 1.11\u20131.97), females (HR = 1.44, 95% CI: 1.11\u20131.89), non\u2010smokers (HR = 1.44, 95% CI: 1.15\u20131.81), nondrinkers (HR = 1.28, 95% CI: 1.04\u20131.57), and individuals with a family history of cancer (HR = 1.37, 95% CI: 1.05\u20131.79). No associations were observed between OL and risk of GCC and GNCC mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OL may increase the long\u2010term risk of ESCC mortality, especially in younger subjects, females, nondrinkers, non\u2010smokers, and subjects with a family cancer history. Future studies are needed to explore the potentially etiological mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13595","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T07:59:24Z","timestamp":1597737564000},"page":"2804-2811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral leukoplakia and the long\u2010term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-3587","authenticated-orcid":false,"given":"Huan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-6733","authenticated-orcid":false,"given":"Su","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-0871","authenticated-orcid":false,"given":"Youlin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0157-3"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"S165","article-title":"Leukoplakia: A short review on malignant potential","volume":"7","author":"Masthan KM","year":"2015","journal-title":"J Pharm Bioallied Sci"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.11.023"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Oral leukoplakia: Present views on diagnosis, management, communication with patients, and research","volume":"6","author":"Waal I","year":"2019","journal-title":"Curr Oral Health Rep"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2298\/MPNS0312552B"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41548-018-0015-y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/321750"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_7_11_1","first-page":"29","article-title":"Some considerations in the design of a nutrition intervention trial in Linxian, People's Republic of China","volume":"69","author":"Blot WJ","year":"1985","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy043"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp037"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.6066"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270170010009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1974.tb01698.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12501"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.07.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008798"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13037"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.225854"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310000700b"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12498"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601509010041"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074646"},{"issue":"2","key":"e_1_2_7_26_1","first-page":"321","article-title":"Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis","volume":"54","author":"Shin DM","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20025"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880220064009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02029.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<418::AID-PATH946>3.0.CO;2-T"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055335"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00770.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17950"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.15171\/joddd.2015.031"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/546318"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.02.008"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8229.114777"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2001.65.4.tb03402.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.038"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1995.tb00025.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200402000-00007"},{"issue":"3","key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00051313","article-title":"Retrospective cohort study of risk\u2010factors for esophageal cancer in Linxian, People's Republic of China","volume":"4","author":"Yu Y","year":"1993","journal-title":"Cancer Causes Control"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(86)90083-6"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20616"},{"issue":"2","key":"e_1_2_7_45_1","first-page":"255","article-title":"The influence of education level on quality of life among patients with esophagus cancer in Henan Province and its coping strategies","volume":"42","author":"L\u2010H R","year":"2015","journal-title":"Mod Prev Med"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1759-7714.13595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:09:51Z","timestamp":1693890591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/1759-7714.13595"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13595","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}