{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:40:04Z","timestamp":1788381604351,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703786"],"award-info":[{"award-number":["81703786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803004"],"award-info":[{"award-number":["81803004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic effect of molecular subtypes on male breast cancer (MBC) remains unclear. The aim of this study was to evaluate the clinicopathological and prognostic factors of MBC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1 January 1990 to 31 December 2014, the data of 152 MBC and 304 female breast cancer (FBC) patients were identified and extensively compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the FBC group, MBC patients were found to have a higher rate of cancer family history (30.9% vs. 18.4%, <jats:italic>P<\/jats:italic> =\u20090.001), mass around the areola area (37.5% vs. 5.6%, <jats:italic>P<\/jats:italic> =\u20090.000), lymph node invasion (44.1% vs. 34.2%, <jats:italic>P<\/jats:italic> =\u20090.006) and hormonal receptor positivity (66.4% vs. 49.3%, <jats:italic>P<\/jats:italic> =\u20090.027). Luminal A was the most common subtype accounting for 69.8%, whereas HER2\u2010positive (12.7%) and TNBC (1.6%) subtypes were rare in the MBC group. However, it was significantly lower for MBC than for FBC who received endocrine therapy (38.8% vs<jats:italic>.<\/jats:italic> 49.3%, <jats:italic>P<\/jats:italic> =\u20090.041). MBC showed the worse overall survival (OS) and disease\u2010free survival (DFS) than those of FBC patients. However, 10\u2010year OS and DFS were similar between MBC and FBC patients in the subgroups of nonluminal subtype (<jats:italic>P<\/jats:italic> &lt;\u20090.001), but worse in MBC patients than those in FBC patients in the subgroups of luminal A (<jats:italic>P<\/jats:italic> =\u20090.004 for OS; <jats:italic>P<\/jats:italic> =\u20090.002 for DFS) and luminal B (<jats:italic>P<\/jats:italic> =\u20090.006 for OS; <jats:italic>P<\/jats:italic> =\u20090.003 for DFS). Multivariate analysis indicated tumor size, radical mastectomy and endocrine therapy as independent risk factors for OS and DFS of MBC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study determined that MBC patients possessed a worse prognosis, usually with lymph node invasion, and were estrogen receptor (ER), progesterone receptor (PR)\u2010positive and human epidermal growth factor receptor (HER2)\u2010negative. Molecular subtypes based on FBC did not provide the same prognostic information in MBC, even in the luminal groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13611","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T08:14:13Z","timestamp":1600330453000},"page":"3107-3116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Male breast cancer: A closer look at patient and tumor characteristics and factors associated with survival"],"prefix":"10.1111","volume":"11","author":[{"given":"Jing","family":"Zhao","sequence":"first","affiliation":[{"name":"Second Department of Breast Surgery Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy  Tianjin China"},{"name":"Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Preventionand Therapy Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Department of Breast Surgery Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy  Tianjin China"},{"name":"Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Preventionand Therapy Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnosis Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnosis Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Department of Breast Surgery Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy  Tianjin China"},{"name":"Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Preventionand Therapy Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-794X","authenticated-orcid":false,"given":"Yanfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Second Department of Breast Surgery Tianjin Medical University Cancer Institute and Hospital  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy  Tianjin China"},{"name":"Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Preventionand Therapy Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05556-y"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"JCO1903120","article-title":"Management of male breast cancer: ASCO guideline","volume":"38","author":"Hassett MJ","year":"2020","journal-title":"J Clin Oncol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.5729"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.01.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2015.12.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45293"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx651"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32472"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-4085-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2648"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191367098"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-664"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(03)00034-3"},{"issue":"10","key":"e_1_2_7_15_1","first-page":"2142","article-title":"Relationship among outcome, stage of disease, and histologic grade for 22,616 cases of breast cancer","volume":"68","author":"Henson DE","year":"1991","journal-title":"The Basis for a Prognostic Index. 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