{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:19Z","timestamp":1747182679566,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Lung cancer sometimes develops on the wall of a giant emphysematous bulla (GEB). Herein, we describe a rare case in which lung cancer developed in lung tissue compressed by GEBs. A 62\u2010year\u2010old man underwent a computed tomography (CT) scan that revealed two right GEBs. A tumor was suspected in the highly compressed right upper lobe. Since the right bronchus was significantly shifted toward the mediastinum, it was difficult to perform a bronchoscopy. We inserted thoracic drains into the GEBs, and a subsequent CT scan revealed re\u2010expansion of the remaining right lung and a 3.3 cm tumor in the right upper lobe. The shift of the right bronchus was improved, and bronchoscopy was performed. The tumor was diagnosed as non\u2010small cell lung cancer (NSCLC). Additionally, the GEBs were found to have originated from the right lower lobe. We performed a right upper lobectomy, mediastinal lymph node dissection, and bullectomy of the GEBs via video\u2010assisted thoracoscopic surgery. In preoperative evaluation of a GEB, assessing re\u2010expansion and lung lesions of the remaining lung is important, and intracavity drainage of a GEB may be useful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:bold>Significant findings of the study<\/jats:bold><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cancer that develops in lung tissue highly compressed by a giant emphysematous bulla is difficult to diagnose.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the preoperative evaluation of a giant emphysematous bulla, assessing re\u2010expansion and lung lesions of the remaining lung is important.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p><jats:bold>What this study adds<\/jats:bold><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>After performing intracavity drainage of a giant emphysematous bulla, the remaining lung re\u2010expands, and the bronchial shift improves; subsequently, bronchoscopy makes it possible to diagnose lung cancer in the remaining lung.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13739","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T08:41:29Z","timestamp":1605084089000},"page":"268-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment strategy for primary lung cancer in a lung highly compressed by giant emphysematous bullae: A case report"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-0894","authenticated-orcid":false,"given":"Nobutaka","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1343-1275","authenticated-orcid":false,"given":"Riki","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Inokawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiga","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Hospital Organization Yamaguchi Ube Medical Center  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.7.634"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2043"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.3.289"},{"key":"e_1_2_6_5_1","first-page":"109","article-title":"Primary lung cancer arising from the wall of a giant bulla","volume":"11","author":"Hirai S","year":"2005","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-010-0618-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs699"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.32.6.668"},{"key":"e_1_2_6_9_1","first-page":"115","article-title":"Intracavitary drainage procedure for giant bullae in compromised patients","volume":"40","author":"Verma RK","year":"1991","journal-title":"Hiroshima J Med Sci"},{"key":"e_1_2_6_10_1","first-page":"317","article-title":"Intracavity drainage under local anesthesia for giant emphysematous bulla and infected bulla","volume":"64","author":"Watanabe T","year":"2011","journal-title":"Kyobu Geka"},{"key":"e_1_2_6_11_1","first-page":"788","article-title":"Re\u2010expansion pulmonary edema following puncture of a giant bulla","volume":"100","author":"McCoskey EH","year":"2000","journal-title":"J Am Osteopath Assoc"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.13739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.13739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T11:10:38Z","timestamp":1693739438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.13739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/1759-7714.13739"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.13739","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"assertion":[{"value":"2020-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}