{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:13:25Z","timestamp":1761808405583,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T00:00:00Z","timestamp":1609027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>About 40% of non\u2010small lung cancer (NSCLC) patients have metastatic disease at the time of diagnosis. However, metastatic NSCLC in the biliary duct system is extremely rare. A high proportion of patients with acute liver failure due to advanced NSCLC do not receive any treatment due to organ dysfunction or poor performance status. Here, we report a case of successful treatment with chemoimmunotherapy in a young woman with obstructive jaundice and acute hepatic failure due to multiple intrahepatic bile duct metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:bold>Significant findings of the study<\/jats:bold><\/jats:p><jats:p>Chemotherapy in NSCLC patients with liver failure is a therapeutic challenge. Acute hepatic failure are often exclusion criteria for therapy of NSCLC. Some reports showed a benefit of ICIs plus chemotherapy for NSCLC with liver metastases.<\/jats:p><jats:p><jats:bold>What this study adds<\/jats:bold><\/jats:p><jats:p>Combination of ICIs and chemotherapy is effective and safe in critically ill patients with lung cancer and impaired liver function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13793","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T04:43:22Z","timestamp":1609130602000},"page":"553-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["To treat or not to treat: A rare case of response to pembrolizumab\u2010based immunotherapy\u2010chemotherapy in non\u2010small cell lung cancer with acute liver failure due to multiple bile duct metastases"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0592-091X","authenticated-orcid":false,"given":"Inna","family":"Shaforostova","sequence":"first","affiliation":[{"name":"Department of Medicine A: Hematology, Hemostaseology, Oncology and Pneumology University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Huss","sequence":"additional","affiliation":[{"name":"Gerhard\u2010Domagk\u2010Institute of Pathology University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Gerwing","sequence":"additional","affiliation":[{"name":"Clinic of Radiology University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Evers","sequence":"additional","affiliation":[{"name":"Department of Medicine A: Hematology, Hemostaseology, Oncology and Pneumology University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalen","family":"Bleckmann","sequence":"additional","affiliation":[{"name":"Department of Medicine A: Hematology, Hemostaseology, Oncology and Pneumology University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181c5920c"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2014.410"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.05.03"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01219"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181dbb727"},{"issue":"01","key":"e_1_2_6_7_1","first-page":"121","article-title":"Metastatic lung cancer to the common bile duct 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