{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:49:44Z","timestamp":1792658984899,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant pleural mesothelioma is an infrequent neoplasia with a poor prognosis and the majority of patients already have advanced disease at the time of presentation. Exposure to asbestos is the most important risk factor for malignant pleural mesothelioma. Mesothelioma is a neoplasia with a long preclinical stage that can span from 15 to 40\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a descriptive, observational, retrospective study of 136 patients with a confirmed diagnosis of mesothelioma, which compared histological subtypes, immunohistochemical biomarkers, concomitant chronic degenerative diseases, tobacco use, age at the time of diagnosis, clinical stage and chemotherapy agents used or other treatments such as radiotherapy and surgery to identify all the factors that impact in the prognosis of overall survival (OS) and progression\u2010free survival (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 136 patients were included in the study. In the total study population, 84 patients were male (61.8%) and 52 were female (38.2%). Median PFS was nine months (95% confidence interval [CI]: 8.4\u20139.5 months) and median OS was 12\u2009months (95% CI: 11.3\u201312.6). The results indicated that the most determining prognostic factors for OS and PFS were cell differentiation measured by immunohistochemical biomarkers, the treatment chosen, and that RECIST was the most significant in the evaluation of patient response to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Malignant pleural mesothelioma is a cancer with a poor prognosis usually diagnosed at an advanced stage of disease. Our study revealed that the prognostic factors for OS and PS were cell differentiation, the treatment chosen and RECIST.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13814","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T12:54:11Z","timestamp":1614862451000},"page":"1014-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic factors for progression\u2010free and overall survival in <scp>malignant pleural mesothelioma<\/scp>"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-2963","authenticated-orcid":false,"given":"Jordi","family":"Guzm\u00e1n\u2010Casta","sequence":"first","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Carrasco\u2010CaraChards","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Guzm\u00e1n\u2010Huesca","sequence":"additional","affiliation":[{"name":"Internal Medicine Bonita Community Health Center, Florida EE.UU.  Bonita Springs Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Paola","family":"S\u00e1nchez\u2010R\u00edos","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Riera\u2010Sala","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Fabi\u00e1n","family":"Mart\u00ednez\u2010Herrera","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Sagrario","family":"Pe\u00f1a\u2010Mirabal","sequence":"additional","affiliation":[{"name":"Department of Pathology Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Bonilla\u2010Molina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ciudad de M\u00e9xico Hopital \u00c1ngeles Lomas  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Arturo","family":"Alatorre\u2010Alexander","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Manuel","family":"Mart\u00ednez\u2010Barrera","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f3nimo Rafael","family":"Rodr\u00edguez\u2010Cid","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Oncology Instituto Nacional de Enfermedades Respiratorias, Dr. Ismael Cos\u00edo Villegas  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.6394"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31826915f1"},{"key":"e_1_2_6_4_1","first-page":"29","article-title":"Mesotelioma pleural maligno","volume":"11","author":"Serna Camancho ME","year":"2012","journal-title":"Gamo"},{"key":"e_1_2_6_5_1","first-page":"19","article-title":"El gneis Novillo y rocas metam\u00f3rficas asociadas en los ca\u00f1ones del Novillo y de La Peregrina, \u00e1rea de Ciudad Victoria, Tamaulipas","volume":"2","author":"Ortega\u2010Guti\u00e9rrez F","year":"1978","journal-title":"Univ Nac Auton Mex Inst Geol Rev"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31817c73d6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22724"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2010.12.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.3943"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01238-6"},{"key":"e_1_2_6_11_1","first-page":"657a","article-title":"Effect of folic acid and vitamin B12 supplmentation on risk\u2010benefit ratio from phase III study of pemetrexed and cisplatin versus cisplatin in malignan pleural mesothelioma","volume":"22","author":"Vogelzang NJ","year":"2003","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5002(95)00508-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.723"},{"key":"e_1_2_6_14_1","first-page":"257","article-title":"Bcl\u20102, p27, p53 y mib\u20101 como factores pron\u00f3stico en pacientes con mesoteliomas pleurales","volume":"30","author":"Romo\u2010S\u00e1nchez MG","year":"2014","journal-title":"Medicina interna de M\u00e9xico"},{"key":"e_1_2_6_15_1","unstructured":"BaasP ScherpereelA NowakAKet al.First\u2010line nivolumab + ipilimumab vs chemotherapy in unresectable malignant pleural mesothelioma: CheckMate743. 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