{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:33Z","timestamp":1747182693297,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Japan, oral administration of tegafur\u2010uracil is recommended as postoperative adjuvant chemotherapy for patients diagnosed with primary lung adenocarcinomas of &gt;2 cm size and staged as IA, IB, and IIA. Reports on chemotherapy\u2010induced pericardial effusion are rare. Herein, we report a rare case of tegafur\u2010uracil\u2010induced pericardial effusion during postoperative adjuvant chemotherapy for primary lung cancer. A 60\u2010year\u2010old man underwent left lower lobectomy and mediastinal lymph node dissection for left lower lung adenocarcinoma. Lung cancer was staged as IB, and tegafur\u2010uracil was administered as postoperative adjuvant chemotherapy from 1 month after the surgery. A computed tomography (CT) scan revealed a pericardial effusion 5 months after the surgery. A malignant pericardial effusion was suspected, and tegafur\u2010uracil was discontinued. Pericardiocentesis could not be performed owing to a small amount of pericardial effusion. An <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG) positron emission tomography\/CT scan revealed no abnormal FDG uptake. During a short follow\u2010up period after discontinuation of tegafur\u2010uracil, a CT scan revealed a decrease in pericardial effusion, suggesting that the pericardial effusion was induced by tegafur\u2010uracil. Follow\u2010up of pericardial effusion is required while administering tegafur\u2010uracil. In cases of pericardial effusion without symptoms and no suspicious metastatic lesions in other organs, we should be concerned about tegafur\u2010uracil\u2010induced pericardial effusion.<\/jats:p>","DOI":"10.1111\/1759-7714.13840","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T07:36:21Z","timestamp":1611041781000},"page":"707-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tegafur\u2010uracil\u2010induced pericardial effusion during adjuvant chemotherapy for resected lung adenocarcinoma: A case report"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-0894","authenticated-orcid":false,"given":"Nobutaka","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1343-1275","authenticated-orcid":false,"given":"Riki","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Inokawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Yamaguchi Ube Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.4.1048"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032792"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.40.1.82"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30342-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.148.3.585"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12763"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2001000500005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007598"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.828.703"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306362"},{"key":"e_1_2_6_13_1","first-page":"906","article-title":"Treatment of malignant pericardial effusion [article in Japanese]","volume":"35","author":"Hosomi Y","year":"2008","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930101)71:1<93::AID-CNCR2820710115>3.0.CO;2-R"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.02.2011.3883"},{"key":"e_1_2_6_16_1","first-page":"360","article-title":"Pericarditis following 5\u2010fluorouracil administration [article in French]","volume":"70","author":"Mar\u00e9chal S","year":"2015","journal-title":"Rev Med Liege"}],"container-title":["Thoracic 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