{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:58:50Z","timestamp":1756191530443,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["XMLX201839"],"award-info":[{"award-number":["XMLX201839"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the long\u2010term outcome of superior vena cava (SVC) replacement after chemotherapy or chemoradiotherapy for advanced thymoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical information of patients with advanced thymoma who underwent thymoma resection and SVC replacement in Beijing Tongren Hospital from 2002 to 2017 were reviewed. We compared surgical outcomes, postoperative complications and long\u2010term prognosis in the chemoradiotherapy + surgery group (CRT\u2009+\u2009surgery group, 19 cases) and the surgery group (26 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The operation time (486.05\u2009\u00b1\u2009148.01 vs. 370.77\u2009\u00b1\u2009124.32\u2009min; <jats:italic>p<\/jats:italic> = 0.007) and intraoperative blood loss (1400\u2009ml [IQR 1125\u20132105\u2009ml] vs. 855\u2009ml [IQR 555\u20131682.5 ml], <jats:italic>p<\/jats:italic> = 0.036), poor wound healing (three cases [15.79%] vs. zero cases [0.0%], <jats:italic>p<\/jats:italic> = 0.036) in the CRT\u2009+\u2009surgery group were significantly higher than those of the surgery group. There was no significant difference between the CRT\u2009+\u2009surgery group and the surgery group in postoperative chest tube drainage time, hospitalization time, postoperative arrhythmia and incidence of pneumonia. Kaplan Meier analysis showed that the recurrence\u2010free survival (RFS) curves of the CRT\u2009+\u2009surgery group patients were better than those of the surgery group (<jats:italic>p<\/jats:italic> = 0.031). However, overall survival (OS) between the two groups was not significantly different (<jats:italic>p<\/jats:italic> = 0.069).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thymoma resection and SVC replacement is feasible for patients undergoing preoperative induction chemotherapy or chemoradiotherapy for advanced thymoma. Although patients in the CRT\u2009+\u2009surgery group had a longer operation time and increased intraoperative bleeding, the RFS rate seemed to be better than that in the surgery group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13872","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T22:37:11Z","timestamp":1613255831000},"page":"1074-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical feasibility and long\u2010term outcome of superior vena cava replacement for advanced thymoma in patients undergoing preoperative chemotherapy or chemoradiotherapy"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-5026","authenticated-orcid":false,"given":"Zhen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Tongren Hospital Capital Medical University  Beijing 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Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Tongren Hospital Capital Medical University  Beijing 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