{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:27:06Z","timestamp":1784348826291,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dry pleural dissemination (DPD) and minimal (&lt;10\u2009mm thick) pleural effusion (PE) may be discovered intraoperatively as unexpected metastases. A definitive diagnostic procedure such as pleural biopsy is rarely attempted in such patients preoperatively. We retrospectively investigated the use and safety of local anesthetic thoracoscopy (LAT) as a pleural staging tool in the diagnosis of DPD and minimal PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 18 patients with non\u2010small cell lung cancer (radiological DPD and minimal PE in 13 and five patients, respectively) who underwent LAT using a flex\u2010rigid pleuroscope for pleural staging from April 2015 to September 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the patients was 72\u2009years. Nine patients (50%) were men. The dominant histological type was adenocarcinoma (<jats:italic>n<\/jats:italic> =\u200916). Three patients each with radiological DPD and minimal PE had visible PE on the LAT. Pleural biopsy was performed in the 16 cases in which pleural abnormalities were identified. On pleural staging, five cases were diagnosed without pleural dissemination (M0), and 13 cases were diagnosed with pleural dissemination (M1a). Only one case in which the lesion could not be identified because of pleural adhesions was false\u2010negative. The success rates for pleural staging, sensitivity, specificity, positive predictive value, and negative predictive value were 94.4% (17\/18), 92.8% (13\/14), 100% (4\/4), 100% (13\/13), and 80.0% (4\/5), respectively. There were no lung lacerations or other severe complications caused by the procedure or during blunt dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LAT might be a useful tool for accurate pleural staging in cases with DPD and minimal PE suspected radiologically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13894","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T09:54:25Z","timestamp":1614246865000},"page":"1195-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pleural staging using local anesthetic thoracoscopy in dry pleural dissemination and minimal pleural effusion"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-5306","authenticated-orcid":false,"given":"Tatsuya","family":"Imabayashi","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Thoracic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Tsuchida","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"47","article-title":"Prognostic value of pleural effusion in patients with non\u2010small cell lung cancer","volume":"3","author":"Sugiura S","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136978"},{"key":"e_1_2_7_5_1","first-page":"665","article-title":"The value of multiple fluid specimens in the cytological diqgnosis of malignancy","volume":"7","author":"Garcia L","year":"1994","journal-title":"Mod 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