{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:47Z","timestamp":1747182707759,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T00:00:00Z","timestamp":1615680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2019GSF108105"],"award-info":[{"award-number":["2019GSF108105"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11971269"],"award-info":[{"award-number":["11971269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of recurrent mediastinal lymph node metastasis (MLNMs) is challenging. We conducted this study to evaluate the effectiveness and safety of computed tomography (CT)\u2010guided percutaneous iodine\u2010125 brachytherapy for MLNMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 33 patients with recurrent MLNMs treated with CT\u2010guided interstitial implantation of iodine\u2010125 seeds. Regular contrast\u2010enhanced CT was conducted to evaluate the tumor response. Follow\u2010up survival, quality of life, and adverse events were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of implanted seeds was 16\u201385 (median, 40). The matched peripheral dose was 110\u2013160\u2009Gy. The patients were followed up for 5\u201324\u2009months (median, 14\u2009months). At the last follow\u2010up or death, complete response to therapy was achieved in 11 patients (33.3%) and partial response in 18 patients (54.5%). The median survival time of this cohort was 15.2 months (95% confidence interval [CI], 9.9\u201320.5 months); the estimated one\u2010 and two\u2010year survival rates were 68.6% and 31.1%, respectively. The Karnofsky performance score increased significantly after the procedure (<jats:italic>p<\/jats:italic> = 0.007). Pneumothorax with pulmonary compression of 30% to 40% occurred in five (15.2%) patients and was cured after drainage. No severe complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT\u2010guided iodine\u2010125 brachytherapy provided a safe and effective choice for recurrent mediastinal lymph node metastasis with significant local therapeutic effects and minor complications, especially for patients who were not eligible for surgical resection and had failed to benefit from systemic therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.13932","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T05:18:42Z","timestamp":1615785522000},"page":"1517-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CT<\/scp>\u2010guided iodine\u2010125 brachytherapy as salvage therapy for recurrent mediastinal lymph node metastasis"],"prefix":"10.1111","volume":"12","author":[{"given":"Hong","family":"Dong","sequence":"first","affiliation":[{"name":"Nursing Department, The Second Hospital, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Operating Room Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianjin","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine Shandong University; Interventional Oncology Institute of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine Shandong University; Interventional Oncology Institute of Shandong University  Jinan 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