{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:48Z","timestamp":1747182708961,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidermal growth factor receptor (EGFR)\u2010tyrosine kinase inhibitors (TKIs) are key drugs in the treatment of non\u2010small cell lung cancer (NSCLC) patients with <jats:italic>EGFR<\/jats:italic> mutations; however, first\u2010generation EGFR\u2010TKIs, such as gefitinib and erlotinib, are not effective in patients with uncommon <jats:italic>EGFR<\/jats:italic> mutations. In contrast, efficacy of afatinib has been reported in some types of uncommon <jats:italic>EGFR<\/jats:italic> mutation such as G710X, L861Q. The effect of afatinib in NSCLC patients with the EGFR K860I mutation has been shown in vitro, but its clinical efficacy has not been demonstrated. Here, we report the experience of afatinib administration in an NSCLC patient with an EGFR K860I mutation. A 69\u2010year\u2010old woman presented with right hemiplegia and dysarthria. Multiple brain and lung tumors were observed. She underwent craniotomy and was diagnosed with lung adenocarcinoma. After stereotactic brain radiation therapy, cisplatin, pemetrexed, and bevacizumab combination therapy was initiated. Unfortunately, she was unable to continue chemotherapy as she had an intestinal perforation after two cycles. After five\u00a0months, recurrence of multiple brain metastases and an increase in primary lung cancer were confirmed. Next\u2010generation sequencing (NGS) was performed in a clinical trial, and an EGFR K860I mutation was detected in her tumor. Afatinib was administered and the primary lung tumor shrank, but multiple brain metastases were exacerbated. After irradiation of the brain, afatinib administration was continued. In conclusion, afatinib may show an effect in NSCLC patients with the EGFR K860I mutation, but its efficacy is limited.<\/jats:p>","DOI":"10.1111\/1759-7714.13941","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T09:24:41Z","timestamp":1620120281000},"page":"1770-1774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Limited effect of afatinib in a non\u2010small cell lung cancer patient harboring an epidermal growth factor receptor <scp>K860I<\/scp> missense mutation: A case report"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-9029","authenticated-orcid":false,"given":"Tomoki","family":"Tamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Kawakado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Makimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamoto","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Kuyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810699"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70393-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.2806"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.7994"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.06.007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12996"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.11.005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2016.1139235"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3935"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913662"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.7576"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00092-2016"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0093"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.02.020"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22297"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.71"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.07.008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9931"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4333"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan6566"}],"container-title":["Thoracic 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