{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:25:39Z","timestamp":1791923139562,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The LungVision system is a novel augmented\u2010fluoroscopy\u2010based real\u2010time navigation and guidance technology for bronchoscopy that can be integrated with any standard biopsy tool, including the cryoprobe, to enable real\u2010time visualization and localization of pulmonary nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the diagnostic yield and safety among patients undergoing peripheral pulmonary nodule biopsy with the LungVision system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, single\u2010center study was conducted at Rabin Medical Center in Israel. All patients that underwent peripheral pulmonary nodule biopsy with the LungVision system from January 2016 to August 2020 were included. All procedures were performed under moderate sedation. The primary outcome was tissue diagnosis by either identification of malignant cells or benign diagnosis. Secondary outcomes were safety and the added value of cryobiopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three procedures were performed during the study period. Median lesion size (interquartile range) was 25.0\u2009mm (18\u201328\u2009mm). The diagnostic yield overall was 27\/33 (81.8%) and for lesions smaller than 20\u2009mm was 13\/18 (72.2%). In nine cases the transbronchial cryobiopsy showed tissue with malignant cells that were not found in any other biopsy material taken with other sampling tools. One patient was treated with a chest tube for a pneumothorax. No other major complications were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LungVision system showed good feasibility and safety for peripheral pulmonary nodule biopsy. The system is compatible with all biopsy tools, including the cryoprobe. Randomized controlled trials are needed to accurately ascertain its diagnostic yield.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14003","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T17:47:15Z","timestamp":1623088035000},"page":"2007-2012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The <scp>LungVision<\/scp> navigational platform for peripheral lung nodule biopsy and the added value of cryobiopsy"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3077-3616","authenticated-orcid":false,"given":"Barak","family":"Pertzov","sequence":"first","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeni","family":"Gershman","sequence":"additional","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Izhakian","sequence":"additional","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Heching","sequence":"additional","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai Moshe","family":"Amor","sequence":"additional","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai Reuven","family":"Kramer","sequence":"additional","affiliation":[{"name":"Pulmonary Division Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201506-1082ST"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207168"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1332OC"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00051-2016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-019-01241-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355710"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-2104OC"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367900"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.145490"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445032"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.02.035"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000499"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13221"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12120"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484055"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381921"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203987"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00033011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00011313"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000566"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13766"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000700"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.08.422"},{"key":"e_1_2_10_25_1","unstructured":"PertzovB UntermanA HechingM GershmanE RosengartenD KramerM. Use of augmented fluoroscopic navigation and guidance technology with transbronchial cryo biopsy to acquire tissue from peripheral lung nodules. In: C110 Interventional Pulmonology: The Swiss Army Knife For Thoracic Oncology [internet]. American Thoracic Society; 2018 [cited 2020 Jun 26]. p. A6154\u2013A6154. (American Thoracic Society International Conference Abstracts). Available from:https:\/\/www.atsjournals.org\/doi\/abs\/10.1164\/ajrccm-conference.2018.197.1_MeetingAbstracts.A6154"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","unstructured":"BhadraK.Artificial intelligence improves patient outcomes for diagnostics of pulmonary nodules during navigational bronchoscopy. In: A72 Advances In Interventional Pulmonary [internet]. American Thoracic Society; 2019 [cited 2020 Jun 26]. p. A2360\u2013A2360. (American Thoracic Society International Conference Abstracts). 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