{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:52:36Z","timestamp":1782604356694,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment of stage IIIB non\u2010small cell lung cancer (NSCLC) is complicated, the best strategy is chosen individually and surgery is usually not recommended. A 50\u2010year\u2010old female was diagnosed with locally advanced lung adenocarcinoma (stage IIIB, T2bN3M0). Fluorescence in situ hybridization (FISH) analysis revealed an ALK rearrangement. Crizotinib was administered and progression was seen after five months. The patient then received ceritinib with a palliative intent, which led to downstaging (IIIA[N2]) with a radiological and metabolic response. Right lower lobe lobectomy was performed at 12\u2009months post\u2010surgery, and the patient is still disease\u2010free according to the last computed tomography (CT) scan. The unintended downstaging from ceritinib provided a chance for resection in our patient who had ALK\u2010positive stage IIIB NSCLC after the failure of first\u2010line crizotinib, indicating potential usage of ceritinib in the neoadjuvant setting. Future perspective trials are warranted to investigate the role of ceritinib in earlier stages as a primary drug.<\/jats:p>","DOI":"10.1111\/1759-7714.14045","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:31:25Z","timestamp":1623249085000},"page":"2130-2133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathological complete response to neoadjuvant ceritinib of a crizotinib\u2010resistant, stage <scp>IIIB<\/scp> non\u2010small cell lung cancer with <scp>ALK<\/scp> rearrangement: A case report"],"prefix":"10.1111","volume":"12","author":[{"given":"Zhongxing","family":"Bing","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Peking Union Medical College Eight\u2010Year MD Program, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Peking Union Medical College Eight\u2010Year MD Program, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Research Center, Central Laboratory Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-4226","authenticated-orcid":false,"given":"Naixin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.10.161"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.903528"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-3927"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.05.036"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2906"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0846"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.08.1320"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T04:22:24Z","timestamp":1693282944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":8,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/1759-7714.14045"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14045","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"2021-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}