{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:21:10Z","timestamp":1781900470284,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to explore the outcomes of computed tomography\u2010guided microwave ablation (MWA) in non\u2010small cell lung cancer (NSCLC) patients with adjacent lobe invasion (ALI), and to compare the outcomes of ALI\u2010NSCLC and non\u2010ALI NSCLC patients after MWA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 319 NSCLC patients and 366 tumors treated with MWA were included in the study, comprising 34 ALI\u2010NSCLC patients and 285 non\u2010ALI NSCLC patients. Complications, local recurrence rates, progression\u2010free survival (PFS), and overall survival (OS) were compared. Logistic regression analyses were used to investigate the correlation between ALI and the occurrence of pneumothorax after MWA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean tumor diameter of ablated tumors was 3.6\u2009\u00b1\u20092.2\u00a0cm. There were 95 (29.8%) NSCLC patients in which pneumothorax occurred after MWA, and all patients recovered. Of these, the ALI group had a significantly higher incidence rate of pneumothorax than the non\u2010ALI group (52.9% vs. 27.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). The median PFS and OS for the ALI group were 12.0\u2009\u00b1\u200910.2 and 15.5\u2009\u00b1\u20099.5\u00a0months, respectively, and that of the non\u2010ALI group were 13.0\u2009\u00b1\u200910.6 and 17.0\u2009\u00b1\u200911.1\u00a0months, respectively, and no significant difference was found in PFS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.329) nor OS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.394) between the two groups. Local recurrence rates for ALI and non\u2010ALI groups were 29.4% and 20.7%, respectively, and no significant difference was found (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.244). Logistic regression analyses revealed that ALI can increase the risk of pneumothorax (hazard ratio [HR], 2.867; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MWA is an effective and safe approach for ALI\u2010NSCLC treatment. Although ALI can increase the risk of pneumothorax, ALI\u2010NSCLC patients reveal a comparable outcome to non\u2010ALI NSCLC patients after MWA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14125","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T13:45:39Z","timestamp":1629812739000},"page":"2780-2788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Computed tomography\u2010guided microwave ablation for the treatment of non\u2010small cell lung cancer patients with and without adjacent lobe invasion: A comparative study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0757-8289","authenticated-orcid":false,"given":"Sheng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Xin","family":"Bie","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run\u2010Qi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3345-1313","authenticated-orcid":false,"given":"Xiao\u2010Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences  Beijing 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