{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:16:50Z","timestamp":1791832610386,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>EGFR<\/jats:italic> mutation has been detected in more than half of non\u2010small cell lung cancer (NSCLC) patients in Asia. Lung cancer is the main cause of malignant tumor\u2010related death worldwide. Although distant metastases often occurs in patients with advanced NSCLC, uterine cervical metastasis is rare. Here, we report a case of <jats:italic>EGFR<\/jats:italic>\u2010mutated lung adenocarcinoma with cervical metastasis. A 63\u2010year\u2010old female with known lung adenocarcinoma was found to have abnormal vaginal bleeding during osimertinib follow\u2010up visits. Immunohistochemical (IHC) staining and next\u2010generation sequencing (NGS) of the biopsy sample from the uterine cervical tumor confirmed metastatic dissemination from the primary lung malignancy. NGS assisted the diagnosis of uterine cervical metastasis from the primary lung. This is another major clinical application of NGS in addition to medication guidance and identification of drug resistance mechanisms.<\/jats:p>","DOI":"10.1111\/1759-7714.14143","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:14:06Z","timestamp":1631232846000},"page":"2622-2627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Next\u2010generation sequencing assisted diagnosis of cervical metastasis in <scp><i>EGFR<\/i><\/scp>\u2010mutated lung adenocarcinoma: A case report"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-2461","authenticated-orcid":false,"given":"Li","family":"Xu","sequence":"first","affiliation":[{"name":"Second Department of Thoracic Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha 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