{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:51Z","timestamp":1747182591649,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we report a case of carbohydrate antigen (CA) 19\u20109\u2010producing mediastinal neuroendocrine tumor (NET) (atypical carcinoid). A 54\u2010year\u2010old woman with no specific relevant medical history was referred to our hospital because of increased CA19\u20109 (95.3\u00a0U\/ml) detected on health screening. Chest computed tomography (CT) revealed an anterior mediastinal mass without localized lymphadenopathy. Thoracic surgery was performed and the histopathological diagnosis was thymic CA19\u20109\u2010positive NET. The patient developed mediastinal lymph node metastasis at 1\u00a0year (CA19\u20109: 413\u2009U\/ml) and multiple bone metastases 4\u2009years (CA19\u20109: 2303\u2009U\/ml) after surgery. Increased CA19\u20109 levels paralleled the clinical courses of relapse. To our knowledge, this is the first report of CA19\u20109\u2010producing thymic NET.<\/jats:p>","DOI":"10.1111\/1759-7714.14153","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T03:33:36Z","timestamp":1632800016000},"page":"2949-2952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased carbohydrate antigen 19\u20109 expression in a thymic neuroendocrine tumor"],"prefix":"10.1111","volume":"12","author":[{"given":"Yuki","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Oncology, Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Internal Medicine, Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-3928","authenticated-orcid":false,"given":"Shintaro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshirou","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Hospital Organization Matsumoto Medical Center  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-0960","authenticated-orcid":false,"given":"Tomonobu","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v12.i12.468"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.10.004"},{"key":"e_1_2_5_4_1","first-page":"6795","article-title":"Carbohydrate antigen 19\u20109 as a prognostic biomarker in pancreatic neuroendocrine tumors","volume":"14","author":"Luo G","year":"2017","journal-title":"Oncol Lett."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5240-z"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12533"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001181"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.04.005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1940"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0304"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP14357.OR"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2010.08.013"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.09.003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.09.124"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0899-7071(94)00003-U"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.01.024"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2407"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:53:06Z","timestamp":1693209186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":17,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/1759-7714.14153"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14153","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2021,9,27]]},"assertion":[{"value":"2021-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}