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Clinically, they are characterized by rapidly increasing anterior mediastinal masses, which can cause compression of the surrounding tissues. The diagnosis of PMBCL mainly depends on the pathological features, imaging examination and clinical features. Currently, the most commonly used therapeutic regimens are R\u2010CHOP and R\u2010EPOCH. Radiotherapy is beneficial in some patients, but it can also lead to long\u2010term toxicity. The research and development of novel therapies are ongoing, and some studies have achieved encouraging results, including those conducted on chimeric antigen receptor\u2010modified T (CAR\u2010T) cell therapy and anti\u2010PD\u20101 drugs. However, randomized controlled trials with larger sample sizes are still needed. Positron emission tomography\u2010computed tomography (PET\u2010CT) is mainly used to assess the curative effect after treatment and to guide the subsequent treatment strategy.<\/jats:p>","DOI":"10.1111\/1759-7714.14155","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T06:32:52Z","timestamp":1632983572000},"page":"2831-2837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Primary mediastinal large <scp>B<\/scp> cell lymphoma"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-8733","authenticated-orcid":false,"given":"Yating","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Hematology, General Hospital Tianjin Medical University  Tianjin 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