{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:47:13Z","timestamp":1777103233614,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Uncertainty after the detection of pulmonary nodules (PNs) can cause psychological burden. We designed this study to quantitatively evaluate the prevalence, severity and possible impact of this burden on the preference of patients for management of nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Hospital Anxiety and Depression Scale (HADS) was used to evaluate psychological burden in patients. An independent <jats:italic>t<\/jats:italic>\u2010test and a Mann\u2013Whitney U test were used to determine the significance of differences between groups in continuous variables. A chi\u2010square test was used to determine the significance of difference between groups in categorical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 334 inpatients diagnosed with PNs were included in the study. A total of 17.96% of the participates screened positive for anxiety and 14.67% for depression. Female patients had significantly higher positive rates of both anxiety and depression screenings than male patients (21.57% vs. 12.31%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.032 and 18.05% vs. 9.30%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.028, respectively). Among patients screened positive for anxiety, the proportion of those who chose more aggressive management was significantly higher (34\/60 vs. 113\/274, <jats:italic>p<\/jats:italic>\u00a0=\u20090.029). The rate of benign or precursor disease resected was significantly higher in patients with more aggressive management (46.94% vs. 9.63%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anxiety and depression are common in Chinese patients with PNs. Patients with positive HADS anxiety screening results are more likely to adopt more aggressive management that leads to a higher rate of benign or precursor disease resected\/biopsied. This study alerts clinicians to the need to assess and possibly treat emotional responses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14165","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T02:42:10Z","timestamp":1634697730000},"page":"3150-3156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A cross\u2010sectional study of psychological burden in <scp>Chinese<\/scp> patients with pulmonary nodules: Prevalence and impact on the management of nodules"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-093X","authenticated-orcid":false,"given":"Rongxin","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Centre of Thoracic Minimally Invasive Surgery Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-1798","authenticated-orcid":false,"given":"Yuqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Haidian Hospital Haidian Section of Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shushi","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Haidian Hospital Haidian Section of Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-7979","authenticated-orcid":false,"given":"Xianping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Centre of Thoracic Minimally Invasive Surgery Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-0953","authenticated-orcid":false,"given":"Xiaoyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Centre of Thoracic Minimally Invasive Surgery Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-2005","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Centre of Thoracic Minimally Invasive Surgery Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Centre of Thoracic Minimally Invasive Surgery Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X08322013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.08.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017161659"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12745"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2018.06.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12036"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.01.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2018-000437"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2948"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5245"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12916"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201779"},{"issue":"6","key":"e_1_2_7_14_1","first-page":"769","article-title":"Problem of diagnosis and follow\u2010up for pulmonary nodules detected on low\u2010dose CT screening","volume":"47","author":"Kazuto A","year":"2007","journal-title":"The 22nd Lung Cancer Mass Screening Seminar"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2351"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0020"},{"issue":"21","key":"e_1_2_7_17_1","first-page":"1604","article-title":"Chinese Medical Doctor Association of Respiratory Doctor Branch Lung Cancer Working Committee. 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