{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:01:57Z","timestamp":1792036917950,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The IMpower133 regimen, composed of atezolizumab\/etoposide (VP\u201016)\/carboplatin (CBDCA), is the standard first\u2010line treatment for extensive\u2010stage small cell lung cancer (ES\u2010SCLC). However, the safety and efficacy of triplet therapy in patients receiving dialysis have not been sufficiently evaluated. Here, we report two cases of dialysis patients with ES\u2010SCLC who received the modified IMpower133 regimen. Patient 1 was a 69\u2010year\u2010old man, and patient 2 was a 73\u2010year\u2010old man who received dialysis because of end\u2010stage renal failure caused by diabetic nephropathy. Both patients received a modified IMpower133 regimen in the following order: atezolizumab (1200\u2009mg\/body) on day 1, VP\u201016 (50\u2009mg\/m<jats:sup>2<\/jats:sup>) on days 1 and 3, and CBDCA (300\u2009mg\/m<jats:sup>2<\/jats:sup>) on day 1. Four hours of dialysis was performed 1\u00a0hour after completing the administration of CBDCA on Day 1 and 2\u00a0hours after completing the administration of VP\u201016 on Day 3. Both patients achieved a partial response and received atezolizumab maintenance therapy after four cycles of triplet therapy without uncontrollable adverse events. By modifying the dosage, the order of drugs, and the timing of dialysis, the IMpower133 regimen may be tolerable and effective for patients receiving dialysis.<\/jats:p>","DOI":"10.1111\/1759-7714.14166","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T02:17:11Z","timestamp":1632968231000},"page":"2956-2960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tolerability and efficacy of <scp>IMpower133<\/scp> regimen modified for dialysis patients with extensive\u2010stage small cell lung cancer: Two case reports"],"prefix":"10.1111","volume":"12","author":[{"given":"Naokazu","family":"Watari","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9117-1934","authenticated-orcid":false,"given":"Kakuhiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-0049","authenticated-orcid":false,"given":"Takeshi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory 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Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.14166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.14166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:53:09Z","timestamp":1693209189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.14166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":10,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/1759-7714.14166"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.14166","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]},"assertion":[{"value":"2021-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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