{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:36:34Z","timestamp":1790094994161,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013060","name":"Jilin Provincial Health and Family Planning Commission","doi-asserted-by":"publisher","award":["2019J077"],"award-info":[{"award-number":["2019J077"]}],"id":[{"id":"10.13039\/501100013060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The presence of pleural effusion is an independent predictor for poor survival in patients with small\u2010cell lung cancer (SCLC). The aim of this study was to assess the efficacy and safety of anlotinib in patients with SCLC and pleural effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blind, multicenter, phase II trial. Patients histologically diagnosed with SCLC and pleural effusion and had received at least two lines of chemotherapy were enrolled into the study. The patients received anlotinib 12\u2009mg\/day or a placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall response rate (ORR) was 3.7% for anlotinib (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) and 0% in the placebo group (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.000). The disease control rate (DCR) of the anlotinib group (63.0%) was higher than that of the placebo group (0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The median progression\u2010free survival (PFS) increased in the anlotinib group (2.8\u00a0months) compared to the placebo group (0.7\u00a0months, HR\u00a0=\u00a00.10, 95% CI: 0.03\u20130.28, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The median overall survival of the anlotinib group (6.5\u00a0months) was higher than that of the placebo group (2.8\u00a0months, HR\u00a0=\u00a00.52, 95% CI: 0.22\u20131.23, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.1285). The incidence of any grade adverse events was 100% in both groups. The percentage of grade 3\u20134 adverse events in the anlotinib group was 44.4% (12\/27) compared to 40.0% (6\/15) in the placebo group. Hypertension (37.0%), fatigue (29.6%), and loss of appetite (29.6%) typically appeared in the anlotinib group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this post hoc analysis, anlotinib was associated with improved PFS in patients with SCLC and baseline pleural effusion. However, additional studies with a large sample size are necessary to substantiate the current findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14176","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T22:23:03Z","timestamp":1633126983000},"page":"3039-3045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of anlotinib in patients with small\u2010cell lung cancer and pleural effusion: Subgroup analysis from a randomized, multicenter, phase <scp>II<\/scp> study"],"prefix":"10.1111","volume":"12","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Thoracic Medical Oncology Jilin Cancer Hospital  Changchun 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Linyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University (Hunan Cancer Hospital)  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shanghai Chest Hospital, Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical 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